Ethyl 2-hydroxy-3-methylbenzoate

Base Information

• Chemical Name: Ethyl 2-hydroxy-3-methylbenzoate
• CAS No.: 55211-85-3
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• European Community (EC) Number: 882-802-8
• NSC Number: 97235
• DSSTox Substance ID: DTXSID30970540
• Nikkaji Number: J414.223C
• Wikidata: Q63398128
• Mol file: 55211-85-3.mol

Synonyms:Ethyl 2-hydroxy-3-methylbenzoate;55211-85-3;NSC97235;SCHEMBL1242911;Ethyl2-hydroxy-3-methylbenzoate;DTXSID30970540;3-Methylsalicylic acid ethyl ester;NSC-97235;AKOS008948331;ETHYL 2-HYDROXY-3-METHYLBEZOATE;CS-0237230;FT-0734552;EN300-180506;A830527;Q63398128

Chemical Property of Ethyl 2-hydroxy-3-methylbenzoate

Chemical Property:

• Vapor Pressure: 0.0103mmHg at 25°C
• Boiling Point: 255.2°Cat760mmHg
• Flash Point: 102.1°C
• Density: 1.136g/cm³
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 180.078644241
• Heavy Atom Count: 13
• Complexity: 179

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C1=CC=CC(=C1O)C

Technology Process of Ethyl 2-hydroxy-3-methylbenzoate

There total 6 articles about Ethyl 2-hydroxy-3-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

ethyl 4-methyl-3-oxohept-6-enoate → ethyl 2-hydroxy-3-methylbenzoate (55211-85-3)

Guidance literature:

With oxygen; copper diacetate; palladium diacetate; In dimethyl sulfoxide; at 45 ℃; for 23h; under 760.051 Torr; chemoselective reaction;

DOI:10.1016/j.tetlet.2019.05.041

Reference yield: 45.0%

(1Z,3Z)-1-Ethoxy-1,3-bis-trimethylsilanyloxy-penta-1,3-diene + malonaldehydebis(dimethylacetal) (102-52-3) → ethyl 2-hydroxy-3-methylbenzoate (55211-85-3)

Guidance literature:

(1Z,3Z)-1-Ethoxy-1,3-bis-trimethylsilanyloxy-penta-1,3-diene; malonaldehydebis(dimethylacetal); With trimethylsilyl trifluoromethanesulfonate; In dichloromethane; at -78 - 20 ℃;

With hydrogenchloride; In dichloromethane; Further stages.;

DOI:10.1021/jo070974a

Reference yield:

ethanol (64-17-5) + 3-methylsalicylic acid (83-40-9) → ethyl 2-hydroxy-3-methylbenzoate (55211-85-3)

Guidance literature:

With hydrogenchloride;

upstream raw materials:

ethanol

3-methylsalicylic acid

2-hydroxy-3-methyl-benzoyl chloride

malonaldehydebis(dimethylacetal)

Downstream raw materials:

6,6'-(1,3,4-oxadiazole-2,5-diyl)bis(2-methylphenol)

N'-(4-methylbenzylidene)2-hydroxy-3-methylbenzohydrazide