Cresotamide

Base Information

• Chemical Name: Cresotamide
• CAS No.: 14008-60-7
• Molecular Formula: C8H9 N O2
• Molecular Weight: 151.165
• Hs Code.: 2924299090
• European Community (EC) Number: 237-821-0
• UNII: 5748P7L6IT
• DSSTox Substance ID: DTXSID40161225
• Nikkaji Number: J8.473E
• Wikidata: Q27261464
• NCI Thesaurus Code: C77351
• ChEMBL ID: CHEMBL2104183
• Mol file: 14008-60-7.mol

Synonyms:2,3-cresotamide

Chemical Property of Cresotamide

Chemical Property:

• Vapor Pressure: 0.00355mmHg at 25°C
• Boiling Point: 272.9°Cat760mmHg
• Flash Point: 118.8°C
• PSA: 63.32000
• Density: 1.23g/cm³
• LogP: 1.49980
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 151.063328530
• Heavy Atom Count: 11
• Complexity: 158

Purity/Quality:

97% ^*data from raw suppliers

2-Hydroxy-3-methylbenzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=C(C(=CC=C1)C(=O)N)O

Technology Process of Cresotamide

There total 9 articles about Cresotamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-methylsalicylic acid methyl ester (23287-26-5) → 2-hydroxy 3-methyl benzamide (14008-60-7)

Guidance literature:

With ammonium hydroxide;

Reference yield:

oxalyl dichloride (79-37-8) + 3-methylsalicylic acid (83-40-9) → 2-hydroxy 3-methyl benzamide (14008-60-7)

Guidance literature:

With hydrogenchloride; In N,N-dimethyl-formamide; benzene;

Reference yield:

3-methylsalicylic acid (83-40-9) → 2-hydroxy 3-methyl benzamide (14008-60-7)

Guidance literature:

Multi-step reaction with 2 steps

1: petroleum ether; PCl₅

2: diethyl ether; NH₃

With diethyl ether; phosphorus pentachloride; ammonia; Petroleum ether;

upstream raw materials:

8-methyl-benzo[e][1,3]oxazine-2,4-dione

3-methylsalicylic acid methyl ester

2-hydroxy-3-methyl-benzoyl chloride

ethyl 2-hydroxy-3-methylbenzoate

Downstream raw materials:

2-carbamoyl-6-methylphenyl acetate

8-methyl-2-(3-nitro-phenyl)-2,3-dihydro-benzo[e][1,3]oxazin-4-one

8-methyl-2-(4-nitro-phenyl)-2,3-dihydro-benzo[e][1,3]oxazin-4-one