2-Chloro-4-methoxybenzoyl chloride

Base Information

Chemical Name:2-Chloro-4-methoxybenzoyl chloride
CAS No.:50424-99-2
Molecular Formula:C8H6Cl2O2
Molecular Weight:205.04
Hs Code.:
DSSTox Substance ID:DTXSID00560871
Wikidata:Q82444494
Mol file:50424-99-2.mol

Synonyms:2-Chloro-4-methoxybenzoyl chloride;50424-99-2;Benzoyl chloride, 2-chloro-4-methoxy-;2-chloro-4-methoxybenzoic acid chloride;BENZOYL CHLORIDE,2-CHLORO-4-METHOXY;SCHEMBL3142619;DTXSID00560871;SYAIPNCFYHEQMA-UHFFFAOYSA-N;EN300-1459144

Suppliers and Price of 2-Chloro-4-methoxybenzoyl chloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 3 raw suppliers

Chemical Property of 2-Chloro-4-methoxybenzoyl chloride

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:203.9744848
Heavy Atom Count:12
Complexity:172

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=C(C=C1)C(=O)Cl)Cl

Technology Process of 2-Chloro-4-methoxybenzoyl chloride

There total 2 articles about 2-Chloro-4-methoxybenzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 56363-84-9
2-chloro-4-hydroxybenzoic acid

: 50424-99-2
2-chloro-4-methoxybenzoic acid chloride

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / NaH / dimethylformamide / 16 h

2: oxalyl chloride / DMF / CH₂Cl₂ / 2.5 h

With oxalyl dichloride; sodium hydride; DMF; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm0612968

Reference yield:

: 41068-36-4
2-chloro-4-methoxyacetophenone

: 50424-99-2
2-chloro-4-methoxybenzoic acid chloride

Guidance literature:: Multi-step reaction with 2 steps

1: 65 percent / Br₂, NaOH / dioxane / 4 h / 60 °C

2: 82 percent / SOCl₂ / Heating

With sodium hydroxide; thionyl chloride; bromine; In 1,4-dioxane;
DOI:10.1002/ardp.19903230204

Reference yield: 93.0%

: 50424-99-2
2-chloro-4-methoxybenzoic acid chloride

: 79099-07-3
N-tert-butyloxycarbonylpiperidin-4-one

: tert-butyl 3-(2-chloro-4-methoxybenzoyl)-4-oxopiperidine-1-carboxylate

Guidance literature:: N-tert-butyloxycarbonylpiperidin-4-one; With potassium hexamethylsilazane; In tetrahydrofuran; toluene; at 0 ℃; for 0.0833333h; Inert atmosphere;

2-chloro-4-methoxybenzoic acid chloride; In tetrahydrofuran; toluene; at 20 ℃; for 1h; Inert atmosphere;