N-(4-Hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-chlor-4-hydroxybenzamid

Base Information

Chemical Name:N-(4-Hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-chlor-4-hydroxybenzamid
CAS No.:127817-94-1
Molecular Formula:C₁₆H₁₃ClF₃NO₃
Molecular Weight:359.732
Hs Code.:

Synonyms:N-(4-Hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-chlor-4-hydroxybenzamid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(4-Hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-chlor-4-hydroxybenzamid

Chemical Property:

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Technology Process of N-(4-Hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-chlor-4-hydroxybenzamid

There total 4 articles about N-(4-Hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-chlor-4-hydroxybenzamid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 127817-89-4
N-(4-Methoxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-chlor-4-methoxybenzamid

: 127817-94-1
N-(4-Hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-chlor-4-hydroxybenzamid

Guidance literature:: With boron tribromide; In dichloromethane; 1) 30 min, -60 deg C 2) 4h, room temperature;
DOI:10.1002/ardp.19903230204

Reference yield:

: 41068-36-4
2-chloro-4-methoxyacetophenone

: 127817-94-1
N-(4-Hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-chlor-4-hydroxybenzamid

Guidance literature:: Multi-step reaction with 4 steps

1: 65 percent / Br₂, NaOH / dioxane / 4 h / 60 °C

2: 82 percent / SOCl₂ / Heating

3: 69 percent / K₂CO₃ / 2 h / 80 °C

4: 57 percent / BBr₃ / CH₂Cl₂ / 1) 30 min, -60 deg C 2) 4h, room temperature

With sodium hydroxide; thionyl chloride; bromine; boron tribromide; potassium carbonate; In 1,4-dioxane; dichloromethane;
DOI:10.1002/ardp.19903230204

Reference yield:

: 21971-21-1
2-chloro-4-methoxybenzoic acid

: 127817-94-1
N-(4-Hydroxyphenyl)-N-(1,1,1-trifluor-2-propyl)-2-chlor-4-hydroxybenzamid

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / SOCl₂ / Heating

2: 69 percent / K₂CO₃ / 2 h / 80 °C

3: 57 percent / BBr₃ / CH₂Cl₂ / 1) 30 min, -60 deg C 2) 4h, room temperature

With thionyl chloride; boron tribromide; potassium carbonate; In dichloromethane;
DOI:10.1002/ardp.19903230204