1-Methyl-3-ethyloxindole

Base Information

• Chemical Name: 1-Methyl-3-ethyloxindole
• CAS No.: 2525-35-1
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Hs Code.: 2933790090
• Mol file: 2525-35-1.mol

Synonyms:2-Indolinone,3-ethyl-1-methyl- (7CI,8CI); 3-Ethyl-1-methyl-2-indolinone;3-Ethyl-N-methyloxindole; Ba 2780; NSC 117184; NSC 62139

Chemical Property of 1-Methyl-3-ethyloxindole

Chemical Property:

• Vapor Pressure: 0.000208mmHg at 25°C
• Boiling Point: 327°Cat760mmHg
• Flash Point: 152.8°C
• PSA: 20.31000
• Density: 1.07g/cm³
• LogP: 2.22160

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Methyl-3-ethyloxindole

There total 17 articles about 1-Methyl-3-ethyloxindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N-(2-iodophenyl)-N-methylbut-2-enamide → 3-ethyl-1-methyl-1,3-dihydro-2H-indol-2-one (2525-35-1)

Guidance literature:

With (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; triethylamine; In acetonitrile; at 35 ℃; for 24h; Reagent/catalyst; Solvent; Catalytic behavior; Irradiation;

DOI:10.1039/c5cc00072f

Reference yield: 72.0%

(E)-But-2-enoic acid (2-bromo-phenyl)-methyl-amide (102804-48-8) → 3-ethyl-1-methyl-1,3-dihydro-2H-indol-2-one (2525-35-1)

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In toluene; Heating;

DOI:10.1039/c39860000115

Reference yield: 68.0%

C11H13ClO2 + methylamine (74-89-5) → 3-ethyl-1-methyl-1,3-dihydro-2H-indol-2-one (2525-35-1)

Guidance literature:

With copper; In neat (no solvent); at 100 ℃; for 24h; Sealed tube;

DOI:10.1039/c7ra08123e

upstream raw materials:

2-bromo-N-methyl-N-phenylbutanamide

(2E)-N-(2-iodophenyl)-N-methylbut-2-enamide

(E)-But-2-enoic acid (2-bromo-phenyl)-methyl-amide

carbon monoxide

Downstream raw materials:

Toluene-4-sulfonic acid 2-(3-ethyl-1-methyl-2-oxo-2,3-dihydro-1H-indol-3-yl)-ethyl ester