2-(3-BROMOPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE

Base Information

• Chemical Name: 2-(3-BROMOPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE
• CAS No.: 51849-84-4
• Molecular Formula: C11H12BrNO
• Molecular Weight: 254.126
• Hs Code.: 2934999090
• Mol file: 51849-84-4.mol

Synonyms:AB3191;

Chemical Property of 2-(3-BROMOPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE

Chemical Property:

• PSA: 21.59000
• LogP: 2.44010

Purity/Quality:

99% ^*data from raw suppliers

2-(3-Bromophenyl)-4,4-dimethyl-4,5-dihydrooxazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(3-BROMOPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE

There total 11 articles about 2-(3-BROMOPHENYL)-4,5-DIHYDRO-4,4-DIMETHYLOXAZOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.9%

3-bromo-N-(2-hydroxy-1,1-dimethylethyl)benzamide (211388-38-4) → 2-(3-bromophenyl)-4,4-dimethyl-2-oxazoline (51849-84-4)

Guidance literature:

With thionyl chloride; In dichloromethane; at 20 ℃; for 1h;

Reference yield:

3-bromobenzoyl chloride (1711-09-7) + 2-Amino-2-methyl-1-propanol (124-68-5) → 2-(3-bromophenyl)-4,4-dimethyl-2-oxazoline (51849-84-4)

Guidance literature:

With potassium hydroxide; In thionyl chloride; dichloromethane; water;

Reference yield:

m-bromobenzoic aldehyde (3132-99-8) → 2-(3-bromophenyl)-4,4-dimethyl-2-oxazoline (51849-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1: dichloromethane / 14 h / Molecular sieve

2: N-Bromosuccinimide; sodium hydrogencarbonate / water / 0.5 h

With N-Bromosuccinimide; sodium hydrogencarbonate; In dichloromethane; water;

DOI:10.1002/ejoc.201403255

upstream raw materials:

m-bromobenzoic acid

2-Amino-2-methyl-1-propanol

3-bromo-N-(2-hydroxy-1,1-dimethylethyl)benzamide

3-bromobenzoyl chloride

Downstream raw materials:

α-<3-(4,4-dimethyloxazolin-2-yl)phenyl>-3-<3-(2-tetrahydropyranyloxy)propyl>benzyl alcohol

1-deoxy-1-<3-(4,5-dihydro-4,4-dimethyl-2-oxazol-2-yl)phenyl>-β-D-ribofuranose

methyl 3-(2,3,5-tri-O-benzyl-1-deoxy-β-D-ribofuranosyl)benzoate

2,3,5-tri-O-benzyl-1-deoxy-1-<3-(4,5-dihydro-4,4-dimethyl-2-oxazol-2-yl)phenyl>-β-D-ribofuranose

Refernces

• 1、 Batista, Joo H. C.,Santos, Fernanda M. Dos,Bozzini, Leandro A.,Vessecchi, Ricardo,Oliveira, Alfredo R. M.,Clososki, Giuliano C.. "Directed functionalization of halophenyl-2-oxazolines with TMPMgCl?LiCl". . p. 967 - 977. Retrieved 2015/02/19.
• 2、 -. "Trityl-type compounds and their use". . . Retrieved 2008/06/13.