3-Methoxyphenyl methanesulfonate

Base Information

• Chemical Name: 3-Methoxyphenyl methanesulfonate
• CAS No.: 52200-03-0
• Molecular Formula: C8H10O4S
• Molecular Weight: 202.231
• Hs Code.: 2909499000
• Mol file: 52200-03-0.mol

Synonyms:3-Methoxyphenyl methanesulfonate

Chemical Property of 3-Methoxyphenyl methanesulfonate

Chemical Property:

• PSA: 60.98000
• LogP: 2.11440

Purity/Quality:

≥95% ^*data from raw suppliers

Phenol,3-methoxy-,1-methanesulfonate 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Methoxyphenyl methanesulfonate

There total 2 articles about 3-Methoxyphenyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

O-methylresorcine (150-19-6) + methanesulfonyl chloride (124-63-0) → 3-methoxyphenyl methanesulfonate (52200-03-0)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1055/s-0034-1379483

Reference yield: 70.0%

methanesulfonic acid (75-75-2,98527-29-8) + 3-methoxybenzenediazonium o-benzenedisulfonimide → 3-methoxyphenyl methanesulfonate (52200-03-0)

Guidance literature:

at 60 ℃; for 0.5h;

DOI:10.1055/s-1999-3696

Reference yield: 99.0%

3-methoxyphenyl methanesulfonate (52200-03-0) + benzamide (55-21-0,27208-38-4) → N-(3-methoxyphenyl)benzamide (13031-49-7)

Guidance literature:

With t-BuBrettPhos; water; palladium diacetate; caesium carbonate; In tert-butyl alcohol; at 110 ℃; for 0.333333h; Inert atmosphere;

DOI:10.1021/ol100720x

upstream raw materials:

O-methylresorcine

methanesulfonyl chloride

methanesulfonic acid

Downstream raw materials:

1-methoxy-3-(propa-1,2-dien-1-yl)benzene

3-methoxybiphenyl

2-(3’-methoxyphenyl)benzofuran

2-(3-methoxyphenyl)-5, 5-dimethyl-1,3,2-dioxaborinane

Refernces

• 1、 Song, Bingrui,Knauber, Thomas,Goo?en, Lukas J.. "Decarboxylative cross-coupling of mesylates catalyzed by copper/palladium systems with customized imidazolyl phosphine ligands". supporting information. p. 2954 - 2958. Retrieved 2013/04/11.
• 2、 Chow, Wing Kin,So, Chau Ming,Lau, Chak Po,Kwong, Fuk Yee. "A general palladium catalyst system for suzuki-miyaura coupling of potassium aryltrifluoroborates and aryl mesylates". supporting information; experimental part. p. 5109 - 5112. Retrieved 2010/09/05.