2-(2-Ethoxyphenoxymethyl)oxirane

Base Information

• Chemical Name: 2-(2-Ethoxyphenoxymethyl)oxirane
• CAS No.: 5296-35-5
• Molecular Formula: C11H14O3
• Molecular Weight: 194.23
• UNII: CWV6JBX8KS
• DSSTox Substance ID: DTXSID301297673
• Mol file: 5296-35-5.mol

Synonyms:2-(2-Ethoxyphenoxymethyl)oxirane;5296-35-5;2-[(2-Ethoxyphenoxy)methyl]oxirane;2-Ethoxyphenyl Glycidyl Ether;1-(2-Ethoxyphenoxy)-2,3-epoxypropane;2-((2-ethoxyphenoxy)methyl)oxirane;Oxirane, [(2-ethoxyphenoxy)methyl]-;starbld0044265;CWV6JBX8KS;SCHEMBL1698264;SCHEMBL26253967;DJOGZXNBSUIGKG-UHFFFAOYSA-N;DTXSID301297673;AKOS000192213;AKOS017283024;3-(2-ethoxyphenoxy)-1,2-epoxypropane;Benzene, 1-(2,3-epoxypropoxy)-2-ethoxy-;FT-0668114

Chemical Property of 2-(2-Ethoxyphenoxymethyl)oxirane

Chemical Property:

• Melting Point: 45 °C
• Boiling Point: 122 °C(Press: 4 Torr)
• PSA: 30.99000
• Density: 1.114±0.06 g/cm3(Predicted)
• LogP: 1.86290
• Storage Temp.: Refrigerator
• Solubility.: Dichloromethane, Ethyl Acetate
• XLogP3: 1.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 194.094294304
• Heavy Atom Count: 14
• Complexity: 172

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Ethoxyphenoxymethyl)oxirane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC=C1OCC2CO2
• Uses: Intermediate in the preparation of Morpholine derivatives.

Technology Process of 2-(2-Ethoxyphenoxymethyl)oxirane

There total 3 articles about 2-(2-Ethoxyphenoxymethyl)oxirane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Ethoxyphenol (94-71-3) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 1,2-Anhydro-3-O-(o-ethoxyphenyl)-glycerol (5296-35-5)

Guidance literature:

With tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; In tert-butyl methyl ether; at 45 ℃; for 48h; Product distribution / selectivity;

Reference yield:

2-Ethoxyphenol (94-71-3) + 1,2-Epoxy-3-bromopropane (3132-64-7,82584-73-4) → 1,2-Anhydro-3-O-(o-ethoxyphenyl)-glycerol (5296-35-5)

Guidance literature:

With tetra-(n-butyl)ammonium iodide; potassium carbonate; In acetonitrile; at 55 ℃;

Reference yield:

→ 1,2-Anhydro-3-O-(o-ethoxyphenyl)-glycerol (5296-35-5)

Guidance literature:

2-Aethoxy-phenol, aq.NaOH (Kuehlung), Epichlorhydrin, 20grad, 24h;

upstream raw materials:

2-Ethoxyphenol

epichlorohydrin

1,2-Epoxy-3-bromopropane

Downstream raw materials:

C₂₀H₂₇NO₄

viloxazine

2-[(2-Ethoxyphenoxy)-methyl]morpholine hydrochloride

(+/-)-4-benzyl-2-(2-ethoxyphenoxymethyl)morpholine