Viloxazine hydrochloride

Base Information

• Chemical Name: Viloxazine hydrochloride
• CAS No.: 35604-67-2
• Molecular Formula: C13H19 N O3 . Cl H
• Molecular Weight: 273.76
• Hs Code.: 2934999090
• European Community (EC) Number: 252-638-6
• UNII: OQW30I1332
• DSSTox Substance ID: DTXSID8057722
• Wikidata: Q27285797
• NCI Thesaurus Code: C152878
• RXCUI: 142143
• ChEMBL ID: CHEMBL2106483
• Mol file: 35604-67-2.mol

Synonyms:Emovit;ICI-58,834;ICI58,834;Viloxazine;Viloxazine Hydrochloride;Viloxazine Hydrochloride, (R)-Isomer;Viloxazine Hydrochloride, (S)-Isomer;Viloxazine Oxalate (1:1);Viloxazine, (+-)-Isomer;Viloxazine, (R)-Isomer;Viloxazine, (S)-Isomer;Vivalan

Chemical Property of Viloxazine hydrochloride

Chemical Property:

• Melting Point: 178-180°C
• Boiling Point: 350.5°Cat760mmHg
• Flash Point: 144.3°C
• PSA: 39.72000
• Density: 1.061g/cm³
• LogP: 2.58330
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly)
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 273.1131712
• Heavy Atom Count: 18
• Complexity: 213

Purity/Quality:

98% ^*data from raw suppliers

racViloxazineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC=C1OCC2CNCCO2.Cl
• Recent ClinicalTrials: Open-label Study to Evaluate Long-term Safety and Efficacy of SPN-812 Extended Release (ER)
• Uses: Antidepressant. Rac Viloxazine Hydrochloride is research useful chemical used as an antidepressant.
• Therapeutic Function: Psychotropic

Technology Process of Viloxazine hydrochloride

There total 4 articles about Viloxazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(+/-)-4-benzyl-2-(2-ethoxyphenoxymethyl)morpholine (47374-79-8) → 2-[(2-Ethoxyphenoxy)-methyl]morpholine hydrochloride (35604-67-2)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In ethanol; at 60 ℃; for 2h;

Reference yield:

2-Ethoxyphenol (94-71-3) → 2-[(2-Ethoxyphenoxy)-methyl]morpholine hydrochloride (35604-67-2)

Guidance literature:

Multi-step reaction with 4 steps

1.1: tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate / tert-butyl methyl ether / 48 h / 45 °C

2.1: toluene / 6 h / Reflux

3.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / toluene / 0.17 h / 20 °C

3.2: 20 - 40 °C

4.1: hydrogenchloride; hydrogen / palladium on activated charcoal / ethanol / 2 h / 60 °C

With hydrogenchloride; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; potassium carbonate; sodium hydroxide; palladium on activated charcoal; In ethanol; tert-butyl methyl ether; toluene;

Reference yield:

C20H27NO4 (1338700-16-5) → 2-[(2-Ethoxyphenoxy)-methyl]morpholine hydrochloride (35604-67-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride / toluene / 0.17 h / 20 °C

1.2: 20 - 40 °C

2.1: hydrogenchloride; hydrogen / palladium on activated charcoal / ethanol / 2 h / 60 °C

With hydrogenchloride; N-benzyl-N,N,N-triethylammonium chloride; hydrogen; sodium hydroxide; palladium on activated charcoal; In ethanol; toluene;

upstream raw materials:

(+/-)-4-benzyl-2-(2-ethoxyphenoxymethyl)morpholine

2-Ethoxyphenol

C₂₀H₂₇NO₄

1,2-Anhydro-3-O-(o-ethoxyphenyl)-glycerol

Downstream raw materials:

viloxazine

Refernces