2,3-Diphenyl-1H-inden-1-ol

Base Information

• Chemical Name: 2,3-Diphenyl-1H-inden-1-ol
• CAS No.: 53347-50-5
• Molecular Formula: C21H16O
• Molecular Weight: 284.357
• DSSTox Substance ID: DTXSID60496501
• Nikkaji Number: J1.670.104A
• Mol file: 53347-50-5.mol

Synonyms:2,3-Diphenyl-1H-inden-1-ol;53347-50-5;DTXSID60496501

Chemical Property of 2,3-Diphenyl-1H-inden-1-ol

Chemical Property:

• PSA: 20.23000
• LogP: 4.69270
• XLogP3: 4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 284.120115130
• Heavy Atom Count: 22
• Complexity: 412

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=C(C3=CC=CC=C3C2O)C4=CC=CC=C4

Technology Process of 2,3-Diphenyl-1H-inden-1-ol

There total 12 articles about 2,3-Diphenyl-1H-inden-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

2-formylbenzene boronic acid (40138-16-7) + diphenyl acetylene (501-65-5) → 2,3-diphenyl-1H-inden-1-ol (53347-50-5)

Guidance literature:

With cobalt acetylacetonate; In acetonitrile; at 80 ℃; for 12h; regioselective reaction; Sealed tube;

DOI:10.1016/j.tetlet.2017.06.049

Reference yield: 85.0%

2-iodobenzaldehyde (26260-02-6) + diphenyl acetylene (501-65-5) → 2,3-diphenyl-1H-inden-1-ol (53347-50-5)

Guidance literature:

With zinc; Karstedt’s catalyst; In acetonitrile; at 80 ℃; for 3h;

DOI:10.1021/ol035514s

Reference yield: 76.0%

o-(phenylethynyl)benzaldehyde (59046-72-9) + phenylboronic acid (98-80-6) → 2,3-diphenyl-1H-inden-1-ol (53347-50-5)

Guidance literature:

With tricyclohexylphosphine; tris(dibenzylideneacetone)dipalladium ⁽⁰⁾; In methanol; at 80 ℃; for 9h;

DOI:10.1021/ol071107v

upstream raw materials:

2,3-diphenyl-1H-inden-1-one

1-chloro-2,3-diphenyl-1H-indene

2-iodobenzaldehyde

diphenyl acetylene

Downstream raw materials:

1-bromo-2,3-diphenyl-1H-indene

1-chloro-2,3-diphenyl-1H-indene

2,3-diphenyl-1H-inden-1-one

(2RS,3RS)-2-phenyl-3-phenyl-2,3-dihydro-1H-inden-1-one