(2-Hydroxyethyl) hydrogen succinate

Base Information

• Chemical Name: (2-Hydroxyethyl) hydrogen succinate
• CAS No.: 21583-38-0
• Molecular Formula: C6H10 O5
• Molecular Weight: 162.142
• Hs Code.: 2918990090
• European Community (EC) Number: 244-457-6
• DSSTox Substance ID: DTXSID40944191
• Nikkaji Number: J226.231B
• Wikidata: Q82921393
• Mol file: 21583-38-0.mol

Synonyms:21583-38-0;(2-Hydroxyethyl) hydrogen succinate;4-(2-hydroxyethoxy)-4-oxobutanoic acid;SCHEMBL683877;DTXSID40944191;EINECS 244-457-6;Succinic acid 1-(2-hydroxyethyl) ester

Chemical Property of (2-Hydroxyethyl) hydrogen succinate

Chemical Property:

• Vapor Pressure: 3.1E-07mmHg at 25°C
• Boiling Point: 377.2°Cat760mmHg
• Flash Point: 161.3°C
• PSA: 83.83000
• Density: 1.316g/cm³
• LogP: -0.61330
• XLogP3: -1.1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 6
• Exact Mass: 162.05282342
• Heavy Atom Count: 11
• Complexity: 142

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C(CC(=O)OCCO)C(=O)O

Technology Process of (2-Hydroxyethyl) hydrogen succinate

There total 3 articles about (2-Hydroxyethyl) hydrogen succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

succinic acid anhydride (108-30-5) + ethylene glycol (107-21-1) → succinic acid mono-(2-hydroxy-ethyl ester) (21583-38-0) + 4,4'-(ethane-1,2-diylbis(oxy))bis(4-oxobutanoic acid) (35415-14-6) + 1,4,9,12-tetraoxacyclohexadecane-5,8,13,16-tetrone (62538-52-7)

Guidance literature:

With Candida antarctica B lipase (Novozyme 435); In toluene; at 30 ℃; for 24h;

DOI:10.1055/s-2005-917099

Reference yield:

succinic acid anhydride (108-30-5) + ethylene glycol (107-21-1) → succinic acid mono-(2-hydroxy-ethyl ester) (21583-38-0)

Guidance literature:

In toluene; at 100 ℃; for 0.5h; Reflux;

DOI:10.1016/j.polymer.2010.08.066

Reference yield:

succinic acid (110-15-6) + ethylene glycol (107-21-1) → succinic acid mono-(2-hydroxy-ethyl ester) (21583-38-0)

Guidance literature:

at 195 - 200 ℃;

upstream raw materials:

succinic acid

ethylene glycol

succinic acid anhydride