4-amino-N-[3-(dimethylamino)propyl]benzamide

Base Information

• Chemical Name: 4-amino-N-[3-(dimethylamino)propyl]benzamide
• CAS No.: 53461-08-8
• Molecular Formula: C12H19N3O
• Molecular Weight: 221.302
• Mol file: 53461-08-8.mol

Synonyms:4-Amino-N-(3-dimethylamino-propyl)-benzamid;N,N-Dimethyl-N'-(4-amino-benzoyl)-propandiyldiamin;4-amino-N-(3-dimethylamino-propyl)-benzamide;4-Amino-benzoesaeure-(3-dimethylamino-propylamid);4-amino-benzoic acid-(3-dimethylamino-propylamide);(4-aminophenyl)-N-[3-(dimethylamino)propyl]carboxamide;

Chemical Property of 4-amino-N-[3-(dimethylamino)propyl]benzamide

Chemical Property:

• PSA: 58.36000
• LogP: 1.92240

Purity/Quality:

99% ^*data from raw suppliers

4-Amino-N-[3-(dimethylamino)propyl]benzamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-amino-N-[3-(dimethylamino)propyl]benzamide

There total 8 articles about 4-amino-N-[3-(dimethylamino)propyl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

4-(N-tert-butoxycarbonyl)aminobenzoic acid (66493-39-8) + 1-amino-3-(dimethylamino)propane (109-55-7) → 4-amino-N-(3-(dimethylamino)propyl)benzamide (53461-08-8)

Guidance literature:

4-(N-tert-butoxycarbonyl)aminobenzoic acid; 1-amino-3-(dimethylamino)propane; With benzotriazol-1-ol; In dichloromethane; N,N-dimethyl-formamide; for 72h;

In dichloromethane; N,N-dimethyl-formamide; for 72h;

With trifluoroacetic acid; at 20 ℃; for 168h;

Reference yield:

N-(3-dimethylamino-propyl)-4-nitro-benzamide (88452-44-2) → 4-amino-N-(3-(dimethylamino)propyl)benzamide (53461-08-8)

Guidance literature:

With hydrogenchloride; hydrogen; palladium on activated charcoal; In methanol; pH=4;

DOI:10.1016/j.ejmech.2003.11.005

Reference yield:

4-nitro-benzoyl chloride (122-04-3) → 4-amino-N-(3-(dimethylamino)propyl)benzamide (53461-08-8)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine; 4-(dimethylamino)pyridine / CH₂Cl₂

2: H₂; HCl / Pd/C / methanol / pH 4

With pyridine; hydrogenchloride; dmap; hydrogen; palladium on activated charcoal; In methanol; dichloromethane;

DOI:10.1016/j.ejmech.2003.11.005

upstream raw materials:

N-(3-dimethylamino-propyl)-4-nitro-benzamide

4-nitro-benzoyl chloride

1-amino-3-(dimethylamino)propane

4-(N-tert-butoxycarbonyl)aminobenzoic acid

Downstream raw materials:

methyl 3-(Z)-[1-{4-[(3-dimethylamino-propyl)-carbamoyl]-phenylamino}-1-phenyl-methylidene]-2-indolinone-6-carboxylate

4-(9-cyclopentyl-7,7-difluoro-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl-amino)-N-(3-dimethyl-amino-propyl)-benzamide

4-(9-cyclobutyl-7,7-difluoro-5-methyl-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-ylamino)-N-(3-dimethylamino-propyl)-benzamide

4-(9-cyclopentyl-5-ethyl-7,7-difluoro-6-oxo-6,7,8,9-tetrahydro-5H-pyrimido[4,5-b][1,4]diazepin-2-yl-amino)-N-(3-dimethyl-amino-propyl)-benzamide

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