methyl 4-(4'-benzyloxy-2'-hydroxy-6'-methylbenzyloxy)-2-hydroxy-3-methoxy-6-methylbenzoate

Base Information

• Chemical Name: methyl 4-(4'-benzyloxy-2'-hydroxy-6'-methylbenzyloxy)-2-hydroxy-3-methoxy-6-methylbenzoate
• CAS No.: 158183-37-0
• Molecular Formula: C₂₅H₂₄O₈
• Molecular Weight: 452.461
• Mol file: 158183-37-0.mol

Synonyms:methyl 4-(4'-benzyloxy-2'-hydroxy-6'-methylbenzyloxy)-2-hydroxy-3-methoxy-6-methylbenzoate

Chemical Property of methyl 4-(4'-benzyloxy-2'-hydroxy-6'-methylbenzyloxy)-2-hydroxy-3-methoxy-6-methylbenzoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 4-(4'-benzyloxy-2'-hydroxy-6'-methylbenzyloxy)-2-hydroxy-3-methoxy-6-methylbenzoate

There total 6 articles about methyl 4-(4'-benzyloxy-2'-hydroxy-6'-methylbenzyloxy)-2-hydroxy-3-methoxy-6-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 61.0%

4-benzyloxy-2-hydroxy-6-methylbenzoic acid (54102-37-3) + methyl 2,4-dihydroxy-3-methoxy-6-methylbenzoate (158183-36-9) → methyl 4-(4'-benzyloxy-2'-hydroxy-6'-methylbenzyloxy)-2-hydroxy-3-methoxy-6-methylbenzoate (158183-37-0)

Guidance literature:

With trifluoroacetic anhydride; In toluene; for 24h; Ambient temperature;

Reference yield:

methyl haematommate (34874-90-3) → methyl 4-(4'-benzyloxy-2'-hydroxy-6'-methylbenzyloxy)-2-hydroxy-3-methoxy-6-methylbenzoate (158183-37-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 83 percent / K₂CO₃ / dimethylformamide / 48 h / Ambient temperature

2: 85-90percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 2 h / Ambient temperature

3: 84 percent / K₂CO₃ / acetone / 22 h / Heating

4: 85 percent / H₂ / 10percent Pd/C / ethyl acetate / 12 h / Ambient temperature

5: 61 percent / trifluoroacetic anhydride / toluene / 24 h / Ambient temperature

With hydrogen; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; palladium on activated charcoal; In dichloromethane; ethyl acetate; N,N-dimethyl-formamide; acetone; toluene;

Reference yield:

bis(benzyloxy)-2,4-formyl-3-methyl-6-benzoate de methyle (72935-22-9) → methyl 4-(4'-benzyloxy-2'-hydroxy-6'-methylbenzyloxy)-2-hydroxy-3-methoxy-6-methylbenzoate (158183-37-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 85-90percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 2 h / Ambient temperature

2: 84 percent / K₂CO₃ / acetone / 22 h / Heating

3: 85 percent / H₂ / 10percent Pd/C / ethyl acetate / 12 h / Ambient temperature

4: 61 percent / trifluoroacetic anhydride / toluene / 24 h / Ambient temperature

With hydrogen; potassium carbonate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; palladium on activated charcoal; In dichloromethane; ethyl acetate; acetone; toluene;

upstream raw materials:

4-benzyloxy-2-hydroxy-6-methylbenzoic acid

methyl 2,4-dihydroxy-3-methoxy-6-methylbenzoate

methyl haematommate

methyl 2,4-dibenzyloxy-3-hydroxy-6-methylbenzoate

Downstream raw materials:

4-benzyloxy-2-(3'-hydroxy-2'-methoxy-4'-methoxycarbonyl-5'-methylphenoxy)-6-methylbenzoic acid

4-hydroxy-2-(3'-hydroxy-2'-methoxy-4'-methoxycarbonyl-5'-methylphenoxy)-6-methylbenzoic acid

benzyl 4-hydroxy-2-(3'-hydroxy-2'-methoxy-4'-methoxycarbonyl-5'-methylphenoxy)-6-methylbenzoate

6-benzyl 2-methyl 3,9-dihydroxy-4-methoxy-1,7-dimethydibenzofuran-2,6-dicarboxylate