2-Hydroxy-4-methylvaleronitrile

Base Information

• Chemical Name: 2-Hydroxy-4-methylvaleronitrile
• CAS No.: 54129-53-2
• Molecular Formula: C6H11NO
• Molecular Weight: 113.159
• Mol file: 54129-53-2.mol

Synonyms:2-Hydroxy-4-methyl-valeronitril;Inakt. α-Oxy-isobutylessigsaeure-nitril;2-hydroxy-4-methyl-valeronitrile;DL-Leucinsaeure-nitril;2-hydroxy-3-methylbutanenitrile;2-hydroxy-4-methyl-pentanenitrile;

Chemical Property of 2-Hydroxy-4-methylvaleronitrile

Chemical Property:

• Boiling Point: 107 °C(Press: 9 Torr)
• PKA: 11.38±0.20(Predicted)
• PSA: 44.02000
• Density: 0.91852 g/cm3
• LogP: 0.91698

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

2-Hydroxy-4-methylpentanenitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Hydroxy-4-methylvaleronitrile

There total 15 articles about 2-Hydroxy-4-methylvaleronitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

trimethylsilyl cyanide (7677-24-9) + isovaleraldehyde (590-86-3) → isovaleraldehyde cyanohydrin (54129-53-2)

Guidance literature:

With potassium tert-butylate; 1,3-bis(mesityl)imidazolium chloride; In tetrahydrofuran; at 20 ℃; for 18h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.7b03279

Reference yield: 90.0%

potassium cyanide + isovaleraldehyde (590-86-3) → isovaleraldehyde cyanohydrin (54129-53-2)

Guidance literature:

With sodium hydrogensulfite; In water; at 0 ℃; for 1.5h;

DOI:10.1002/adsc.201701282

Reference yield: 70.0%

potassium cyanide (151-50-8) + isovaleraldehyde (590-86-3) → isovaleraldehyde cyanohydrin (54129-53-2)

Guidance literature:

With acetic acid; In diethyl ether; water;

DOI:10.1007/BF00952205

upstream raw materials:

hydrogen cyanide

isovaleraldehyde

isobutyraldehyde

2-hydroxy-2-methylpropanenitrile

Downstream raw materials:

N,N-dibenzyl-leucine nitrile

2-Benzyloxy-4-methyl-pentanenitrile

LEUCINE

hydrogen cyanide