4-Methoxy-1-Methylpyridin-2(1H)-one

Base Information

• Chemical Name: 4-Methoxy-1-Methylpyridin-2(1H)-one
• CAS No.: 41759-19-7
• Molecular Formula: C7H9NO2
• Molecular Weight: 139.154
• Mol file: 41759-19-7.mol

Synonyms:N-Methyl-4-methoxy-pyridon-(2);4-methoxy-1-methyl-2-pyridone;4-methoxy-N-methylpyridone-2;4-Methoxy-1-methyl-pyridon-(2);4-methoxy-1-methylpyridin-2(1H)-one;4-methoxy-1-methyl-1H-pyridin-2-one;4-Methoxy-1-methyl-1H-pyridin-2-on;4-methoxy-1-methyl-2(1H)-pyridone;

Chemical Property of 4-Methoxy-1-Methylpyridin-2(1H)-one

Chemical Property:

• Vapor Pressure: 0.000797mmHg at 25°C
• Melting Point: 170-171 °C
• Boiling Point: 305.9°Cat760mmHg
• PKA: -0.10±0.62(Predicted)
• Flash Point: 138.8°C
• PSA: 31.23000
• Density: 1.13g/cm³
• LogP: 0.39390

Purity/Quality:

97% ^*data from raw suppliers

4-methoxy-1-methylpyridin-2(1H)-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Methoxy-1-Methylpyridin-2(1H)-one

There total 15 articles about 4-Methoxy-1-Methylpyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-methoxy-1-methyl-3-(phenylsulfonyl)pyridin-2(1H)-one (870854-85-6) → 4-methoxy-1-methyl-2-pyridone (41759-19-7)

Guidance literature:

With sodium dithionite; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; In water; toluene; at 90 ℃;

DOI:10.1016/j.tetlet.2005.09.095

Reference yield: 91.0%

4-methoxypyridin-2(1H)-one (52545-13-8) + methyl iodide (74-88-4) → 4-methoxy-1-methyl-2-pyridone (41759-19-7)

Guidance literature:

4-methoxypyridin-2(1H)-one; With potassium tert-butylate; tetra-(n-butyl)ammonium iodide; In tetrahydrofuran; at 0 ℃; for 0.25h;

methyl iodide; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/j.tetlet.2005.09.095

Reference yield: 50.0%

4-hydroxy-2-pyridone (626-03-9) + dimethyl sulfate (77-78-1) → 4-methoxy-1-methyl-2-pyridone (41759-19-7)

Guidance literature:

With sodium hydroxide; benzyltriethylammonium bromide; In benzene; at 70 ℃; for 96h;

upstream raw materials:

diazomethane

1,2-dihydro-4-hydroxy-1-methyl-2-oxopyridine

2,4-dimethoxypyridine

methyl iodide

Downstream raw materials:

1,1,6,6-Tetraphenyl-hexa-2,4-diyne-1,6-diol; compound with 4-methoxy-1-methyl-1H-pyridin-2-one

1:1 complex of 4-methoxy-1-methylpyridone and (R,R)-(-)-1,6-bis(o-chlorophenyl)-1,6-diphenylhexa-2,4-diyne-1,6-diol

3-(α-hydroxybenzyl)-4-methoxy-1-methyl-2(1H)-pyridone

[(4R,5R)-5-(Hydroxy-diphenyl-methyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-diphenyl-methanol; compound with 4-methoxy-1-methyl-1H-pyridin-2-one