2-Methoxyhydrocinnamic acid methyl ester

Base Information

• Chemical Name: 2-Methoxyhydrocinnamic acid methyl ester
• CAS No.: 55001-09-7
• Molecular Formula: C11H14O3
• Molecular Weight: 194.23
• Hs Code.: 2918990090
• Mol file: 55001-09-7.mol

Synonyms:o-CH3OC6H4(CH2)2CO2CH3;Methyl 3-(2-methoxyphenyl)propionate;3-(2-methoxyphenyl)-propionic acid methyl ester;Benzenepropanoic acid,2-methoxy-,methyl ester;methyl 3-(o-methoxyphenyl)-propanoate;3-(2-Methoxy-phenyl)-propionsaeure-methylester;

Chemical Property of 2-Methoxyhydrocinnamic acid methyl ester

Chemical Property:

• Vapor Pressure: 0.0105mmHg at 25°C
• Refractive Index: n20/D1.512
• Boiling Point: 263oC at 760 mmHg
• Flash Point: 104.4oC
• PSA: 35.53000
• Density: 1.062g/cm3
• LogP: 1.80080

Purity/Quality:

98.5% ^*data from raw suppliers

Methyl3-(2-Methoxyphenyl)Propanoate ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36-52/53
• Safety Statements: 26-61

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2-Methoxyhydrocinnamic acid methyl ester

There total 18 articles about 2-Methoxyhydrocinnamic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

methanol (67-56-1) + 2-methoxy-benzenepropanoic acid (6342-77-4) → methyl 3-(2-methoxyphenyl)propanoate (55001-09-7)

Guidance literature:

With sulfuric acid; for 2.5h; Reflux; Inert atmosphere;

DOI:10.1016/j.bmc.2014.03.012

Reference yield: 96.0%

methyl 2-methoxycinnamate (98288-15-4) → methyl 3-(2-methoxyphenyl)propanoate (55001-09-7)

Guidance literature:

With methanol; (4,4'-di-tert-butyl-2,2'-dipyridyl)-bis-(2-phenylpyridine(-1H))-iridium(III) hexafluorophosphate; diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; at 20 ℃; for 16h; Inert atmosphere; Irradiation; Sealed tube;

DOI:10.1002/adsc.202000751

Reference yield: 89.0%

2-methoxy-benzenepropanoic acid (6342-77-4) + carbonic acid dimethyl ester (616-38-6) → methyl 3-(2-methoxyphenyl)propanoate (55001-09-7)

Guidance literature:

With Novozym 435; acylase I from Aspergillus melleus; amano lipase AK from pseudomonas fluorescens; lipase from wheat germ; papaine; In toluene; at 40 ℃; for 48h; Mechanism; Enzymatic reaction;

DOI:10.1016/j.molcatb.2014.02.020

upstream raw materials:

methanol

2-methoxy-benzenepropanoic acid

3-(2-hydroxyphenyl)propionic acid

dimethyl sulfate

Downstream raw materials:

3-(2-methoxyphenyl)propan-1-ol

3-(2-methoxyphenyl)propanehydrazide

methyl 3-[5-(2,4-dihydroxybenzoyl)-2-hydroxyphenyl] propanoate

6-(2-fluoro-4-hydroxybenzoyl)-2-chromanone