N-Cyclohexyl-4-methylbenzene-1-sulfinamide

Base Information

• Chemical Name: N-Cyclohexyl-4-methylbenzene-1-sulfinamide
• CAS No.: 55552-83-5
• Molecular Formula: C₁₃H₁₉NOS
• Molecular Weight: 237.366
• DSSTox Substance ID: DTXSID40492804
• Nikkaji Number: J2.967.544I
• Mol file: 55552-83-5.mol

Synonyms:55552-83-5;SCHEMBL10282878;DTXSID40492804;N-Cyclohexyl-4-methylbenzene-1-sulfinamide

Chemical Property of N-Cyclohexyl-4-methylbenzene-1-sulfinamide

Chemical Property:

• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 237.11873540
• Heavy Atom Count: 16
• Complexity: 230

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)S(=O)NC2CCCCC2

Technology Process of N-Cyclohexyl-4-methylbenzene-1-sulfinamide

There total 5 articles about N-Cyclohexyl-4-methylbenzene-1-sulfinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

methyl p-toluene sulfinate (672-78-6) + cyclohexylamine (108-91-8,157973-60-9) → N-cyclohexyl-4-methylbenzenesulfinamide (55552-83-5,74225-51-7)

Guidance literature:

cyclohexylamine; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere;

methyl p-toluene sulfinate; In tetrahydrofuran; hexane; Inert atmosphere; Cooling;

DOI:10.1055/s-0030-1259682

Reference yield: 70.0%

cyclohexylamine (108-91-8,157973-60-9) + p-toluenesulfonyl chloride (98-59-9) → N-cyclohexyl-4-methylbenzenesulfinamide (55552-83-5,74225-51-7)

Guidance literature:

With triphenylphosphine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1002/chem.201002885

Reference yield: 68.0%

cyclohexylamine (108-91-8,157973-60-9) + p-toluenesulfonyl chloride (98-59-9) → N-cyclohexyl-4-methylbenzenesulfinamide (55552-83-5,74225-51-7) + N-cyclohexyl-p-toluenesulfonamide (80-30-8)

Guidance literature:

With triphenylphosphine; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1002/chem.201002885

upstream raw materials:

cyclohexylamine

p-toluenesulfonyl chloride

methyl p-toluene sulfinate

p-tolylsulfinyl amide

Downstream raw materials:

C₁₃H₂₀N₂OS

1-(p-tolylsulfinyl)aniline

toluene-4-sulfinic acid cyclohexyl-morpholin-4-ylmethyl-amide