1-Pivaloylpiperidine

Base Information

• Chemical Name: 1-Pivaloylpiperidine
• CAS No.: 55581-65-2
• Molecular Formula: C10H19NO
• Molecular Weight: 169.26400
• Mol file: 55581-65-2.mol

Synonyms:3-p-Methylphenyl-2-isoxazolin;3-(p-Tolyl)-2-isoxazolin;3-p-tolyl-4,5-dihydro-isoxazole;3-(p-Methyl)-benzyl-Δ2-isoxazolin;

Chemical Property of 1-Pivaloylpiperidine

Chemical Property:

• Boiling Point: 115 °C(Press: 10 Torr)
• PKA: -0.41±0.20(Predicted)
• PSA: 20.31000
• Density: 0.949±0.06 g/cm3(Predicted)
• LogP: 1.98290

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Pivaloylpiperidine

There total 5 articles about 1-Pivaloylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

piperidine (110-89-4) + pivaloyl chloride (3282-30-2) → 2,2-dimethyl-1-(piperidin-1-yl)propan-1-one (55581-65-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 23 ℃; for 12h; Inert atmosphere;

Reference yield: 81.0%

piperidine (110-89-4) + pivalaldehyde (630-19-3) → 2,2-dimethyl-1-(piperidin-1-yl)propan-1-one (55581-65-2)

Guidance literature:

With tert.-butylhydroperoxide; copper(l) iodide; sodium hydride; 1,3-bis(mesityl)imidazolium chloride; In acetonitrile; at 90 ℃; for 6h; Inert atmosphere; Schlenk technique;

DOI:10.1055/a-1343-5203

Reference yield: 17.0%

piperidine (110-89-4) + tert-Butyl iodide (558-17-8) + molybdenum hexacarbonyl (13939-06-5,199620-15-0) → 2,2-dimethyl-1-(piperidin-1-yl)propan-1-one (55581-65-2)

Guidance literature:

With tributyl-amine; fac-tris[2-phenylpyridinato-C²,N]iridium(III); diethyl 2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate; In acetonitrile; at 70 ℃; for 20h; under 1725.17 Torr; Sealed tube; Inert atmosphere; Irradiation; Green chemistry;

DOI:10.1002/chem.201601694

upstream raw materials:

piperidine

pivaloyl chloride

Thiopivalinsaeure-O-methylester

Trimethylacetic acid