4-Benzyloxy-3-methoxystyrene

Base Information

• Chemical Name: 4-Benzyloxy-3-methoxystyrene
• CAS No.: 55708-65-1
• Molecular Formula: C16H16O2
• Molecular Weight: 240.302
• Hs Code.: 29093090
• European Community (EC) Number: 259-771-9
• DSSTox Substance ID: DTXSID60204249
• Nikkaji Number: J236.718A
• Wikidata: Q83077692
• Mol file: 55708-65-1.mol

Synonyms:4-Benzyloxy-3-methoxystyrene;55708-65-1;1-(Benzyloxy)-2-methoxy-4-vinylbenzene;4-ethenyl-2-methoxy-1-phenylmethoxybenzene;2-Benzyloxy-5-vinylanisole;EINECS 259-771-9;SCHEMBL348043;2-(Benzyloxy)-5-vinylanisole;DTXSID60204249;4-Benzyloxy-3-methoxystyrene, 97%;AKOS015889062;4-ethenyl-2-methoxy-1-benzyloxybenzene;1-(benzyloxy)-4-ethenyl-2-methoxybenzene;1-(Benzyloxy)-2-methoxy-4-vinylbenzene #;FT-0617656;Benzene, 4-ethenyl-2-methoxy-1-(phenylmethoxy)-

Chemical Property of 4-Benzyloxy-3-methoxystyrene

Chemical Property:

• Appearance/Colour: pale yellow powder
• Vapor Pressure: 2.23E-05mmHg at 25°C
• Melting Point: 49-54 °C (lit.)
• Refractive Index: 1.584
• Boiling Point: 371.3 °C at 760 mm
• Flash Point: 147.6 °C
• PSA: 18.46000
• Density: 1.072 g/cm³
• LogP: 3.91720
• XLogP3: 3.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 240.115029749
• Heavy Atom Count: 18
• Complexity: 246

Purity/Quality:

98%Min ^*data from raw suppliers

4-Benzyloxy-3-methoxystyrene 97% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: COC1=C(C=CC(=C1)C=C)OCC2=CC=CC=C2

Technology Process of 4-Benzyloxy-3-methoxystyrene

There total 10 articles about 4-Benzyloxy-3-methoxystyrene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-methoxy-4-(phenylmethoxy)benzaldehyde (2426-87-1) + Methyltriphenylphosphonium bromide (1779-49-3) → 1-(benzyloxy)-4-ethenyl-2-methoxybenzene (55708-65-1)

Guidance literature:

Methyltriphenylphosphonium bromide; With potassium tert-butylate; In tetrahydrofuran; at 0 - 20 ℃; Inert atmosphere;

3-methoxy-4-(phenylmethoxy)benzaldehyde; In tetrahydrofuran; for 2h;

Reference yield: 77.2%

3-methoxy-4-(phenylmethoxy)benzaldehyde (2426-87-1) + methyl-triphenylphosphonium iodide (2065-66-9) → 1-(benzyloxy)-4-ethenyl-2-methoxybenzene (55708-65-1)

Guidance literature:

With sodium hydride; In tetrahydrofuran; at 80 ℃; for 0.166667h; microwave conditions;

DOI:10.1016/j.bmcl.2006.09.046

Reference yield: 63.0%

dimethylsulfone (67-71-0) + 4-benzyloxy-3-methoxybenzyl alcohol (33693-48-0) → 1-(benzyloxy)-4-ethenyl-2-methoxybenzene (55708-65-1)

Guidance literature:

With C₁₅H₂₅Cl₂N₃NiO₃; potassium tert-butylate; In toluene; at 110 ℃; for 12h; Schlenk technique; Inert atmosphere;

DOI:10.1039/c9cc02603g

upstream raw materials:

(4-benzyloxy-3-methoxy-phenethyl)-trimethyl-ammonium; iodide

3-methoxy-4-(phenylmethoxy)benzaldehyde

methyl-triphenylphosphonium iodide

benzyl chloride

Downstream raw materials:

4-Ethylguaiacol

(E,5S)-1,7-di[4-(benzyloxy)-3-methoxyphenyl]-5-[(4-methoxybenzyl)oxy]-1-hepten-3-one

(E,5S)-1,7-di[4-(benzyloxy)-3-methoxyphenyl]-5-hydroxy-1-hepten-3-one

(1S,4E)-1-[4-(benzyloxy)-3-methoxyphenethyl]-5-[4-(benzyloxy)-3-methoxyphenyl]-3-oxo-4-pentenyl acetate

Refernces

• 1、 Koolaji, Nooshin,Abu-Mellal, Abdallah,Tran, Van H.,Duke, Rujee K.,Duke, Colin C.. "Synthesis of C- and O-prenylated tetrahydroxystilbenes and O-prenylated cinnamates and their action towards cancer cells". supporting information. p. 415 - 422. Retrieved 2013/07/27.
• 2、 Su, Na,Wang, Zhen-Jun,Wang, Li-Zhong,Zhang, Xiao,Dong, Wei-Li,Wang, Hong-Xue,Li, Zheng-Ming,Zhao, Wei-Guang. "Synthesis and biological evaluation of isosteric analogs of mandipropamid for the control of oomycete pathogens". scheme or table. p. 101 - 111. Retrieved 2012/06/01.