[1,3]Dioxolo[6,7][2]benzopyrano[3,4-g]indol-7(1H)-one,2,3,3a,4,5,5a,12b,12c-octahydro-5-hydroxy-1-methyl-, (3aR,5R,5aS,12bS,12cR)-

Base Information

• Chemical Name: [1,3]Dioxolo[6,7][2]benzopyrano[3,4-g]indol-7(1H)-one,2,3,3a,4,5,5a,12b,12c-octahydro-5-hydroxy-1-methyl-, (3aR,5R,5aS,12bS,12cR)-
• CAS No.: 29073-38-9
• Molecular Formula: C₁₇H₁₉NO₅
• Molecular Weight: 317.342
• Mol file: 29073-38-9.mol

Synonyms:Clividine(8CI); Lycorenan-7-one,4,12-dihydro-5-hydroxy-1-methyl-9,10-[methylenebis(oxy)]-, (5b,12b)-; Clividin;[1,3]Dioxolo[6,7][2]benzopyrano[3,4-g]indol-7(1H)-one,2,3,3a,4,5,5a,12b,12c-octahydro-5-hydroxy-1-methyl-, [3aR-(3aa,5a,5ab,12bb,12ca)]-

Chemical Property of [1,3]Dioxolo[6,7][2]benzopyrano[3,4-g]indol-7(1H)-one,2,3,3a,4,5,5a,12b,12c-octahydro-5-hydroxy-1-methyl-, (3aR,5R,5aS,12bS,12cR)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of [1,3]Dioxolo[6,7][2]benzopyrano[3,4-g]indol-7(1H)-one,2,3,3a,4,5,5a,12b,12c-octahydro-5-hydroxy-1-methyl-, (3aR,5R,5aS,12bS,12cR)-

There total 32 articles about [1,3]Dioxolo[6,7][2]benzopyrano[3,4-g]indol-7(1H)-one,2,3,3a,4,5,5a,12b,12c-octahydro-5-hydroxy-1-methyl-, (3aR,5R,5aS,12bS,12cR)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

methanol (67-56-1) + C24H23NO7 → (+/-)-Clivonin (477-16-7,11014-01-0,19504-94-0,29073-38-9,31984-89-1,42337-20-2,42337-21-3,94130-80-0,115587-27-4)

Guidance literature:

With formaldehyd; 5%-palladium/activated carbon; hydrogen; at 20 ℃; for 48h; under 15201 Torr; Inert atmosphere;

DOI:10.1002/ejoc.201500265

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + (+/-)-1-(4-chlorobenzyl)-1-desmethylclivonine → (+/-)-Clivonin (477-16-7,11014-01-0,19504-94-0,29073-38-9,31984-89-1,42337-20-2,42337-21-3,94130-80-0,115587-27-4)

Guidance literature:

With 20 % Pd(OH)2/C; hydrogen; In methanol; ethyl acetate; at 20 ℃; for 5h;

DOI:10.1039/c0ob00895h

Reference yield:

C17H21NO5 → (+/-)-Clivonin (477-16-7,11014-01-0,19504-94-0,29073-38-9,31984-89-1,42337-20-2,42337-21-3,94130-80-0,115587-27-4)

Guidance literature:

With Ag₂CO₃ supported on celite; In toluene; at 80 ℃; for 1h;

DOI:10.1021/ja910184j

upstream raw materials:

formaldehyd