{4-[Methyl(1,3-thiazol-2-yl)amino]phenyl}acetic acid

Base Information

Chemical Name:{4-[Methyl(1,3-thiazol-2-yl)amino]phenyl}acetic acid
CAS No.:56355-26-1
Molecular Formula:C₁₂H₁₂N₂O₂S
Molecular Weight:248.305
Hs Code.:
DSSTox Substance ID:DTXSID90509794
Wikidata:Q82367659

Synonyms:56355-26-1;{4-[Methyl(1,3-thiazol-2-yl)amino]phenyl}acetic acid;SCHEMBL11586604;DTXSID90509794

Suppliers and Price of {4-[Methyl(1,3-thiazol-2-yl)amino]phenyl}acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of {4-[Methyl(1,3-thiazol-2-yl)amino]phenyl}acetic acid

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:248.06194880
Heavy Atom Count:17
Complexity:267

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN(C1=CC=C(C=C1)CC(=O)O)C2=NC=CS2

Technology Process of {4-[Methyl(1,3-thiazol-2-yl)amino]phenyl}acetic acid

There total 7 articles about {4-[Methyl(1,3-thiazol-2-yl)amino]phenyl}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: [4-(1-Methyl-thioureido)-phenyl]-acetic acid ethyl ester

: 621-62-5
chloroacetaldehyde diethyl acetal

: 56355-26-1
[4-(methyl-thiazol-2-yl-amino)-phenyl]-acetic acid

Guidance literature:: With hydrogenchloride; In isopropyl alcohol; at 90 - 95 ℃; for 6h; Yield given;
DOI:10.1248/cpb.31.3424

Reference yield:

: 68787-97-3
N-methyl-4-ethoxycarbonylmethylaniline

: 56355-26-1
[4-(methyl-thiazol-2-yl-amino)-phenyl]-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / NH₄SCN / acetone / 1 h / Ambient temperature

2: K₂CO₃ / methanol; H₂O / 9 h / Heating

3: 20percent HCl / aq. propan-2-ol / 6 h / 90 - 95 °C

With hydrogenchloride; ammonium thiocyanate; potassium carbonate; In methanol; water; isopropyl alcohol; acetone;
DOI:10.1248/cpb.31.3424

Reference yield:

: 5438-70-0
ethyl (4-amino-3,5-dibromophenyl)acetate

: 56355-26-1
[4-(methyl-thiazol-2-yl-amino)-phenyl]-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / CH₂Cl₂ / 1 h / Ambient temperature

2: K₂CO₃ / dimethylformamide / 3 h / Ambient temperature

3: metallic sodium/abs. ethanol / 0.5 h / Ambient temperature

4: 97 percent / NH₄SCN / acetone / 1 h / Ambient temperature

5: K₂CO₃ / methanol; H₂O / 9 h / Heating

6: 20percent HCl / aq. propan-2-ol / 6 h / 90 - 95 °C

With hydrogenchloride; ethanol; ammonium thiocyanate; sodium; potassium carbonate; In methanol; dichloromethane; water; N,N-dimethyl-formamide; isopropyl alcohol; acetone;
DOI:10.1248/cpb.31.3424