6-methylenetetrahydro-2H-pyran-2-one

Base Information

Chemical Name:6-methylenetetrahydro-2H-pyran-2-one
CAS No.:5636-66-8
Molecular Formula:C6H8O2
Molecular Weight:112.128
Hs Code.:
DSSTox Substance ID:DTXSID801286586
Nikkaji Number:J1.398.300C

Synonyms:6-methylideneoxan-2-one;5636-66-8;6-methylenetetrahydro-2H-pyran-2-one;2H-Pyran-2-one, tetrahydro-6-methylene-;SCHEMBL5357477;DTXSID801286586;6-methylene-tetrahydro-pyran-2-one;AKOS037645838;Tetrahydro-6-methylene-2H-pyran-2-one;AS-63944;D93802

Suppliers and Price of 6-methylenetetrahydro-2H-pyran-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of 6-methylenetetrahydro-2H-pyran-2-one

Chemical Property:

PSA：26.30000
LogP:1.22720
XLogP3:0.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:0
Exact Mass:112.052429494
Heavy Atom Count:8
Complexity:127

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C=C1CCCC(=O)O1

Technology Process of 6-methylenetetrahydro-2H-pyran-2-one

There total 2 articles about 6-methylenetetrahydro-2H-pyran-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 6089-09-4
4-pentynoic acid

: 53293-00-8
hex-5-ynoic acid

: 10008-73-8
5-methylenedihydrofuran-2-one

: 5636-66-8
6-methylidenetetrahydro-2-pyrone

Guidance literature:: With bis(benzonitrile)palladium(II) dichloride; triethylamine; In tetrahydrofuran; at 60 ℃; for 6h; Inert atmosphere;
DOI:10.3987/COM-12-S(N)96

Reference yield:

: 53293-00-8
hex-5-ynoic acid

: 3128-06-1
5-ketohexanoic acid

: 5636-66-8
6-methylidenetetrahydro-2-pyrone

Guidance literature:: With gold(at)interfacially cross-linked reversemicelle; In benzene-d6; at 20 ℃; for 8h; Overall yield = 60 %;
DOI:10.1021/ja501277j

Reference yield: 83.0%

: 5636-66-8
6-methylidenetetrahydro-2-pyrone

: 100-63-0
phenylhydrazine

: 1136-87-4
3-(2-methyl-1H-indol-3-yl)propanoic acid

Guidance literature:: With [bis(trifluoromethanesulfonyl)imidate](triphenylphosphine)gold(I); toluene-4-sulfonic acid; In toluene; at 100 ℃; for 2h; regioselective reaction; Inert atmosphere;
DOI:10.1002/ejoc.201001114