2-hydrazinyl-3-(4-methylphenyl)-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one

Base Information

Chemical Name:2-hydrazinyl-3-(4-methylphenyl)-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one
CAS No.:5705-18-0
Molecular Formula:C14H16N2O
Molecular Weight:228.294
Hs Code.:
DSSTox Substance ID:DTXSID80362077
Wikidata:Q82144811

Synonyms:2-hydrazinyl-3-(4-methylphenyl)-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one;5705-18-0;Oprea1_053252;DTXSID80362077;STK833106;AKOS005623092;AB00094071-01;287491-51-4

Suppliers and Price of 2-hydrazinyl-3-(4-methylphenyl)-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 2-hydrazinyl-3-(4-methylphenyl)-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one

Chemical Property:

XLogP3:4.1
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:372.19501140
Heavy Atom Count:28
Complexity:697

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)N2C(=O)C3=C(C4=CC=CC=C4CC35CCCC5)N=C2NN

Technology Process of 2-hydrazinyl-3-(4-methylphenyl)-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one

There total 5 articles about 2-hydrazinyl-3-(4-methylphenyl)-3H-spiro[benzo[h]quinazoline-5,1'-cyclopentan]-4(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 530740-41-1
2-[(4-methoxy-benzyl)-phenyl-amino]-isoindole-1,3-dione

: 5705-18-0
1-(4-methoxybenzyl)-1-phenylhydrazine

Guidance literature:: With hydrazine hydrate; In ethanol; Heating;
DOI:10.1081/SCC-120015563

Reference yield:

: 345928-21-4
2-((4-methoxybenzyl)amino)isoindoline-1,3-dione

: 5705-18-0
1-(4-methoxybenzyl)-1-phenylhydrazine

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / Cu(OAc)2; Et₃N / CH₂Cl₂ / 14 h / Heating

2: 94 percent / hydrazine hydrate / ethanol / Heating

With copper diacetate; hydrazine hydrate; triethylamine; In ethanol; dichloromethane;
DOI:10.1081/SCC-120015563

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 5705-18-0
1-(4-methoxybenzyl)-1-phenylhydrazine

Guidance literature:: Multi-step reaction with 4 steps

1: 80 percent / HCl conc. / dioxane / 0.25 h / 25 °C

2: 80 percent / pyridine*BH₃; AcOH / 0.25 h / 25 °C

3: 82 percent / Cu(OAc)2; Et₃N / CH₂Cl₂ / 14 h / Heating

4: 94 percent / hydrazine hydrate / ethanol / Heating

With hydrogenchloride; copper diacetate; borane pyridine; hydrazine hydrate; acetic acid; triethylamine; In 1,4-dioxane; ethanol; dichloromethane;
DOI:10.1081/SCC-120015563