5-Bromo-4-methoxy-N,N-dimethyl-2-pyrimidinamine

Base Information

• Chemical Name: 5-Bromo-4-methoxy-N,N-dimethyl-2-pyrimidinamine
• CAS No.: 57054-84-9
• Molecular Formula: C7H10BrN3O
• Molecular Weight: 232.07800
• Mol file: 57054-84-9.mol

Synonyms:5-Bromo-4-methoxy-N,N-dimethyl-2-pyrimidinamine;2-Pyrimidinamine,5-bromo-4-methoxy-N,N-dimethyl;5-Brom-2-dimethylamino-4-methoxypyrimidin;

Chemical Property of 5-Bromo-4-methoxy-N,N-dimethyl-2-pyrimidinamine

Chemical Property:

• PSA: 38.25000
• LogP: 1.31370

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Bromo-4-methoxy-N,N-dimethyl-2-pyrimidinamine

There total 2 articles about 5-Bromo-4-methoxy-N,N-dimethyl-2-pyrimidinamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

dimethyl amine (124-40-3) + 5-bromo-2-chloro-4-methoxypyrimidine (57054-92-9) → (5-bromo-4-methoxy-pyrimidin-2-yl)-dimethyl-amine (57054-84-9)

Guidance literature:

In tetrahydrofuran; at 20 - 45 ℃; for 0.5h;

Reference yield:

→ (5-bromo-4-methoxy-pyrimidin-2-yl)-dimethyl-amine (57054-84-9)

Guidance literature:

/BRN= 880106/ 6a, Me2NH/EtOH;

Reference yield:

(5-bromo-4-methoxy-pyrimidin-2-yl)-dimethyl-amine (57054-84-9) → 4-[5-(5-chloro-1-methyl-2-oxo-1,2-dihydro-pyridin-3-yl)-2-(2-dimethylamino-4-methoxy-pyrimidin-5-yl)-3-isopropyl-6-oxo-3,4,5,6-tetrahydro-pyrrolo[3,4-d]imidazol-4-yl] benzonitrile (1448867-39-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 10 h / 105 °C / Inert atmosphere

2: potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane; water / 0.25 h / 80 - 110 °C / Inert atmosphere

With potassium phosphate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium acetate; In 1,4-dioxane; water;

upstream raw materials:

dimethyl amine

5-bromo-2-chloro-4-methoxypyrimidine

Downstream raw materials:

5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-2-methyl-phenyl)-2-(2-dimethylamino-4-methoxy-pyrimidin-5-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-2-(2-dimethylamino-4-methoxy-pyrimidin-5-yl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-d]imidazol-4-one

4-[5-(5-chloro-2-methyl-phenyl)-2-(2-dimethylamino-4-methoxy-pyrimidin-5-yl)-3-isopropyl-6-oxo-3,4,5,6-tetrahydro-pyrrolo[3,4-d]imidazol-4-yl]-benzonitrile

4-[5-(5-chloro-1-methyl-6-oxo-1,6-dihydro-pyridin-3-yl)-2-(2-dimethylamino-4-methoxy-pyrimidin-5-yl)-3-isopropyl-6-oxo-3,4,5,6-tetrahydro-pyrrolo[3,4-d]imidazol-4-yl]-benzonitrile