5-Hydroxy-7,8,4'-trimethoxyflavone

Base Information

Chemical Name:5-Hydroxy-7,8,4'-trimethoxyflavone
CAS No.:57096-03-4
Molecular Formula:C18H16O6
Molecular Weight:328.31600
Hs Code.:
DSSTox Substance ID:DTXSID901169082
Metabolomics Workbench ID:24450
Wikidata:Q104667395

Synonyms:5-Hydroxy-7,8,4'-trimethoxyflavone;Isoscutellarein 7,8,4'-trimethyl ether;5-Hydroxy-4',7,8-trimethoxyflavone;5-Hydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one;SCHEMBL6365437;CHEBI:174400;DTXSID901169082;LMPK12111367;57096-03-4;5-hydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)chromen-4-one

Suppliers and Price of 5-Hydroxy-7,8,4'-trimethoxyflavone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 5-Hydroxy-7,8,4'-trimethoxyflavone

Chemical Property:

PSA：78.13000
LogP:3.19140
XLogP3:3.3
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:328.09468823
Heavy Atom Count:24
Complexity:482

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3O)OC)OC

Technology Process of 5-Hydroxy-7,8,4'-trimethoxyflavone

There total 13 articles about 5-Hydroxy-7,8,4'-trimethoxyflavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 89456-41-7
5,8-dihydroxy-7-methoxy-2-(4-methoxyphenyl)-4-benzopyrone

: 77-78-1
dimethyl sulfate

: 57096-03-4
5-hydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)-4-benzopyrone

Guidance literature:: With potassium carbonate; In acetone; for 3h; Heating;
DOI:10.1016/j.tet.2004.01.023

Reference yield:

: 6601-67-8
4'-benzyloxy-5,7,8-trimethoxyflavone

: 57096-03-4
5-hydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)-4-benzopyrone

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / Pd-C

2: AlCl₃ / nitrobenzene / Ambient temperature

3: K₂CO₃ / acetone / 5 h / Heating

With aluminium trichloride; hydrogen; potassium carbonate; palladium on activated charcoal; In nitrobenzene; acetone;
DOI:10.1248/cpb.28.717

Reference yield:

: 1486-51-7
p-(benzyloxy)benzoic acid

: 57096-03-4
5-hydroxy-7,8-dimethoxy-2-(4-methoxyphenyl)-4-benzopyrone

Guidance literature:: Multi-step reaction with 6 steps

1: (CF₃CO)2O / benzene / 4 h / Ambient temperature

2: KOH / pyridine / 0.33 h / 110 °C

3: conc. H₂SO₄ / acetic acid / 0.12 h / 110 °C

4: H₂ / Pd-C

5: AlCl₃ / nitrobenzene / Ambient temperature

6: K₂CO₃ / acetone / 5 h / Heating

With potassium hydroxide; aluminium trichloride; sulfuric acid; hydrogen; potassium carbonate; trifluoroacetic anhydride; palladium on activated charcoal; In pyridine; acetic acid; nitrobenzene; acetone; benzene;
DOI:10.1248/cpb.28.717