5-Chloro-2,3-dihydro-1,4-dioxine

Base Information

• Chemical Name: 5-Chloro-2,3-dihydro-1,4-dioxine
• CAS No.: 57253-40-4
• Molecular Formula: C4H5ClO2
• Molecular Weight: 120.535
• DSSTox Substance ID: DTXSID00497618
• Wikidata: Q82347289
• Mol file: 57253-40-4.mol

Synonyms:57253-40-4;5-chloro-2,3-dihydro-1,4-dioxine;5-chloro-2,3-dihydro-1,4-dioxin;2-Chloro-2-dioxene;1,4-Dioxin, 5-chloro-2,3-dihydro-;SCHEMBL1627178;DTXSID00497618

Chemical Property of 5-Chloro-2,3-dihydro-1,4-dioxine

Chemical Property:

• Boiling Point: 38-39 °C(Press: 12 Torr)
• PSA: 18.46000
• Density: 1.29±0.1 g/cm3(Predicted)
• LogP: 1.07090
• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 119.9978071
• Heavy Atom Count: 7
• Complexity: 89.7

Purity/Quality:

2-Chloro-2-dioxene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(=CO1)Cl
• Uses: 2-Chloro-2-dioxene is an intermediate in the synthesis of 4-(2-Aminophenyl)-3-morpholinone (A625985). 4-(2-Aminophenyl)-3-morpholinone is a reagent used in the preparation of various Morpholine based pharmaceuticals.

Technology Process of 5-Chloro-2,3-dihydro-1,4-dioxine

There total 2 articles about 5-Chloro-2,3-dihydro-1,4-dioxine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dichloro-1,4-dioxane (95-59-0) → 5-chloro-2,3-dihydro-1,4-dioxin (57253-40-4)

Guidance literature:

Reference yield:

→ 5-chloro-2,3-dihydro-1,4-dioxin (57253-40-4)

Guidance literature:

Darst. nach Zitat;

DOI:10.1039/jr9630003510

Reference yield:

5-chloro-2,3-dihydro-1,4-dioxin (57253-40-4) + methanol (67-56-1) → (2-Chloro-ethoxy)-acetic acid methyl ester (83881-47-4)

Guidance literature:

at 110 ℃; for 1.5h;

DOI:10.1021/jo01069a034

upstream raw materials:

2,3-dichloro-1,4-dioxane

Downstream raw materials:

(2-Chloro-ethoxy)-acetic acid methyl ester

(2-chloro-ethoxy)-acetic acid ethyl ester

Aethylenglykol-bis-(2-chlor-aethoxyacetat)

2-Chlor-ethoxyessigsaeure-<4-methoxy-phenylester>