Octaethylene glycol di(p-toluenesulfonate)

Base Information

Chemical Name:Octaethylene glycol di(p-toluenesulfonate)
CAS No.:57436-38-1
Molecular Formula:C30H46O13S2
Molecular Weight:678.819
Hs Code.:
DSSTox Substance ID:DTXSID20438088
Nikkaji Number:J1.237.142J
Wikidata:Q82253715
Mol file:57436-38-1.mol

Synonyms:57436-38-1;Tos-PEG8-Tos;Octaethylene glycol di(p-toluenesulfonate);3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diyl bis(4-methylbenzenesulfonate);2-[2-[2-[2-[2-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate;SCHEMBL18644929;DTXSID20438088;BP-21826;HY-140369;CS-0114665;C70485;A915053;J-523823;1,23-Bis(tosyloxy)-3,6,9,12,15,18,21-heptaoxatricosane;3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diyl bis(4-methylbenzene-1-sulfonate);3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diylbis(4-methylbenzenesulfonate);23-[(4-methylbenzenesulfonyl)oxy]-3,6,9,12,15,18,21-heptaoxatricosan-1-yl 4-methylbenzene-1-sulfonate

Suppliers and Price of Octaethylene glycol di(p-toluenesulfonate)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diylbis(4-methylbenzenesulfonate) 98%
1g
$ 942.00

BroadPharm
Tos-PEG9-Tos 98%
1 G
$ 550.00

BroadPharm
Tos-PEG9-Tos 98%
500 MG
$ 380.00

Apolloscientific
Tos-PEG9-Tos
500mg
$ 740.00

Acrotein
Tos-PEG8-Tos 97%
0.5g
$ 366.70

Total 9 raw suppliers

Chemical Property of Octaethylene glycol di(p-toluenesulfonate)

Chemical Property:

PSA：168.11000
LogP:4.69200
XLogP3:1.9
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:13
Rotatable Bond Count:28
Exact Mass:678.23798386
Heavy Atom Count:45
Complexity:831

Purity/Quality:

97% ^*data from raw suppliers

3,6,9,12,15,18,21-Heptaoxatricosane-1,23-diylbis(4-methylbenzenesulfonate) 98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)OCCOCCOCCOCCOCCOCCOCCOCCOS(=O)(=O)C2=CC=C(C=C2)C
Description Tos-PEG9-Tos is a PEG linker containing two tosyl groups. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Technology Process of Octaethylene glycol di(p-toluenesulfonate)

There total 4 articles about Octaethylene glycol di(p-toluenesulfonate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 5117-19-1
octaethylene glycol

: 98-59-9
p-toluenesulfonyl chloride

: 57436-38-1
3,6,9,12,15,18,21-heptaoxatricosane-1,23-diyl bis(4-methylbenzenesulfonate)

Guidance literature:: With potassium hydroxide; triethylamine; In tetrahydrofuran; water;
DOI:10.1021/jo990620m

Reference yield:

: 37860-51-8
tetraethylene glycol di(p-toluenesulfonate)

: 57436-38-1
3,6,9,12,15,18,21-heptaoxatricosane-1,23-diyl bis(4-methylbenzenesulfonate)

Guidance literature:: Multi-step reaction with 3 steps

1: NaH / tetrahydrofuran / 24 h

2: 97 percent / H₂ / Pd/C / CH₂Cl₂ / 48 h / 20 °C / 38000 Torr

3: 99 percent / Et₃N; KOH / tetrahydrofuran; H₂O

With potassium hydroxide; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; 1: Etherification / 2: Hydrogenolysis / 3: Tosylation;
DOI:10.1021/jo990620m

Reference yield:

: 112-60-7
Tetraethylene glycol

: 57436-38-1
3,6,9,12,15,18,21-heptaoxatricosane-1,23-diyl bis(4-methylbenzenesulfonate)

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / Et₃N; KOH / tetrahydrofuran; H₂O / 7 h

2: NaH / tetrahydrofuran / 24 h

3: 97 percent / H₂ / Pd/C / CH₂Cl₂ / 48 h / 20 °C / 38000 Torr

4: 99 percent / Et₃N; KOH / tetrahydrofuran; H₂O

With potassium hydroxide; hydrogen; sodium hydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; water; 1: Tosylation / 2: Etherification / 3: Hydrogenolysis / 4: Tosylation;
DOI:10.1021/jo990620m