Ethanedione, (2-bromo-4-pyridinyl)(4-fluorophenyl)-, 1-oxime

Base Information

Chemical Name:Ethanedione, (2-bromo-4-pyridinyl)(4-fluorophenyl)-, 1-oxime
CAS No.:581098-30-8
Molecular Formula:C13H8BrFN2O2
Molecular Weight:323.121
Hs Code.:

Synonyms:2-(2-bromopyridin-4-yl)-1-(4-fluorophenyl)-ethan-1,2-dion-2-oxime;1-(2-Bromo-pyridin-4-yl)-2-(4-fluoro-phenyl)-ethane-1,2-dione 1-oxime;1-(2-bromopyridin-4-yl)-2-(4-fluorophenyl)-ethane-1,2-dione-1-oxime;

Suppliers and Price of Ethanedione, (2-bromo-4-pyridinyl)(4-fluorophenyl)-, 1-oxime

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of Ethanedione, (2-bromo-4-pyridinyl)(4-fluorophenyl)-, 1-oxime

Chemical Property:

Melting Point:214 °C
Boiling Point:470.5±45.0 °C(Predicted)
PSA：62.55000
Density:1.58±0.1 g/cm3(Predicted)
LogP:3.04440

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:

Useful:

Technology Process of Ethanedione, (2-bromo-4-pyridinyl)(4-fluorophenyl)-, 1-oxime

There total 5 articles about Ethanedione, (2-bromo-4-pyridinyl)(4-fluorophenyl)-, 1-oxime which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 158876-70-1
2-(2-bromopyridin-4-yl)-1-(4-fluorophenyl)ethan-1-one

: 581098-30-8
1-(2-bromopyridin-4-yl)-2-(4-fluorophenyl)ethane-1,2-dione 1-oxime

Guidance literature:: With acetic acid; sodium nitrite; In water; at 10 ℃;
DOI:10.1021/jm100161q

Reference yield:

: 4926-28-7
2-Bromo-4-picoline

: 581098-30-8
1-(2-bromopyridin-4-yl)-2-(4-fluorophenyl)ethane-1,2-dione 1-oxime

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium bis(trimethylsilyl)amide / tetrahydrofuran / 0.75 h / 0 °C

1.2: 87 percent / tetrahydrofuran / 1.5 h / 0 - 20 °C

2.1: 82 percent / NaNO₂ / H₂O; acetic acid / 1 h / 20 °C

With sodium hexamethyldisilazane; sodium nitrite; In tetrahydrofuran; water; acetic acid;
DOI:10.1016/j.tetlet.2006.07.147

Reference yield:

: 116332-54-8
4-fluoro-N-methoxy-N-methylbenzamide

: 581098-30-8
1-(2-bromopyridin-4-yl)-2-(4-fluorophenyl)ethane-1,2-dione 1-oxime

Guidance literature:: Multi-step reaction with 2 steps

1.1: LDA / tetrahydrofuran; hexane / -85 °C

1.2: 94 percent / tetrahydrofuran; hexane / -85 - 0 °C

2.1: 76 percent / aq. NaNO₂; AcOH / 10 - 20 °C

With acetic acid; lithium diisopropyl amide; sodium nitrite; In tetrahydrofuran; hexane;
DOI:10.1021/jm030766k