propyl thiophene-2-carboxylate

Base Information

• Chemical Name: propyl thiophene-2-carboxylate
• CAS No.: 59303-19-4
• Molecular Formula: C8H10O2S
• Mol file: 59303-19-4.mol

Synonyms:

Chemical Property of propyl thiophene-2-carboxylate

Chemical Property:

• Vapor Pressure: 0.0459mmHg at 25°C

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of propyl thiophene-2-carboxylate

There total 4 articles about propyl thiophene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

propan-1-ol (71-23-8) + 2-thiophenylcarboxylic acid (527-72-0) → propyl thiophene‐2‐carboxylate (59303-19-4)

Guidance literature:

With silphos; at 20 ℃; for 0.166667h; Neat (no solvent);

DOI:10.1080/00397911.2011.555903

Reference yield: 60.0%

thiophene (188290-36-0,8014-23-1,25233-34-5) + propan-1-ol (71-23-8) + tetrachloromethane (56-23-5) → propyl thiophene‐2‐carboxylate (59303-19-4)

Guidance literature:

With iron(III)-acetylacetonate; at 140 ℃; for 6h; Inert atmosphere; Autoclave;

DOI:10.1134/S0965544108060121

Reference yield:

2-bromothiophene (1003-09-4) + carbon monoxide (201230-82-2) + propyl di-tert-butylphosphinite → propyl thiophene‐2‐carboxylate (59303-19-4)

Guidance literature:

With palladium diacetate; at 115 ℃; for 18h; under 15001.5 Torr; Autoclave; Inert atmosphere;

DOI:10.1039/c7cc02828h

upstream raw materials:

propan-1-ol

2-Thiophenecarbonyl chloride

2-thiophenylcarboxylic acid

thiophene

Refernces

• 1、 Rao, Ambati Narasimha,Ganesan, Kumaran,Shinde, Chandra Kant. "Solvent-free esterification of carboxylic acids and alcohols in the presence of silphos [PCl3-n(SiO2)n] as a heterogeneous phosphine reagent". experimental part. p. 2299 - 2308. Retrieved 2012/06/18.