3H-1,4-Benzodiazepin-2-amine, 7-chloro-5-(2-chlorophenyl)-N-methyl-

Base Information

• Chemical Name: 3H-1,4-Benzodiazepin-2-amine, 7-chloro-5-(2-chlorophenyl)-N-methyl-
• CAS No.: 59467-71-9
• Molecular Formula: C16H13Cl2N3
• Molecular Weight: 318.20100

Synonyms:[7-chloro-5-(2-chloro-phenyl)-3H-benzo[e][1,4]diazepin-2-yl]-methyl-amine;3H-1,4-Benzodiazepin-2-amine,7-chloro-5-(2-chlorophenyl)-N-methyl;7-Chloro-5-(2-chlorophenyl)-2-methylamino-3H-1,4-benzodiazepine;

Chemical Property of 3H-1,4-Benzodiazepin-2-amine, 7-chloro-5-(2-chlorophenyl)-N-methyl-

Chemical Property:

• PSA: 36.75000
• LogP: 3.85820

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3H-1,4-Benzodiazepin-2-amine, 7-chloro-5-(2-chlorophenyl)-N-methyl-

There total 3 articles about 3H-1,4-Benzodiazepin-2-amine, 7-chloro-5-(2-chlorophenyl)-N-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

delorazepam (2894-67-9) → [7-chloro-5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-ylidene]-methyl-amine (59467-71-9)

Guidance literature:

Multi-step reaction with 2 steps

1: P₂S₅; NaHCO₃ / acetonitrile / 24 h / Heating

2: acetonitrile; H₂O / 3 h / 20 °C

With tetraphosphorus decasulfide; sodium hydrogencarbonate; In water; acetonitrile;

DOI:10.1055/s-2004-831243

Reference yield:

methylamine (74-89-5) + 7-chloro-1,3-dihydro-5-(o-chlorophenyl)-2H-1,4-benzodiazepine-2-thione (2894-71-5,49853-64-7) → [7-chloro-5-(2-chloro-phenyl)-1,3-dihydro-benzo[e][1,4]diazepin-2-ylidene]-methyl-amine (59467-71-9)

Guidance literature:

In water; acetonitrile; at 20 ℃; for 3h;

DOI:10.1055/s-2004-831243

Reference yield:

→ [7-chloro-5-(2-chloro-phenyl)-3H-benzo[e][1,4]diazepin-2-yl]-methyl-amine (59467-71-9)

Guidance literature:

7-Chlor-5-<2-chlorphenyl>-1,3-dihydro-2H-1,4-benzodiazepin-2-on, CH3NH2;

upstream raw materials:

methylamine

7-chloro-1,3-dihydro-5-(o-chlorophenyl)-2H-1,4-benzodiazepine-2-thione

delorazepam

Downstream raw materials:

8-chloro-6-(2-chlorophenyl)-3-(4-toluenesulfonyl)-4H-imidazo[1,5-a][1,4]benzodiazepine

7-chloro-5-(2-chlorophenyl)-2-(N-nitrosomethylamino)-3H-1,4-benzodiazepine

2-acetaminomethyl-7-chloro-5-(2-chlorophenyl)-2,3-dihydro-1H-1,4-benzodiazepine

[7-Chloro-5-(2-chloro-phenyl)-3H-benzo[e][1,4]diazepin-2-yl]-(3-methoxy-propyl)-methyl-amine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 59467-71-9 3H-1,4-Benzodiazepin-2-amine, 7-chloro-5-(2-chlorophenyl)-N-methyl-

Send

Send

Metric Ton KG G Pound L ML

Send

Send