2-Amino-4-phenyl-4,5-dihydrofuran-3-carbonitrile

Base Information

Chemical Name:2-Amino-4-phenyl-4,5-dihydrofuran-3-carbonitrile
CAS No.:59790-95-3
Molecular Formula:C11H10N2O
Molecular Weight:186.213
Hs Code.:
DSSTox Substance ID:DTXSID60540159
Nikkaji Number:J1.791.232A

Synonyms:59790-95-3;2-Amino-4-phenyl-4,5-dihydrofuran-3-carbonitrile;DTXSID60540159

Suppliers and Price of 2-Amino-4-phenyl-4,5-dihydrofuran-3-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-Amino-4-phenyl-4,5-dihydrofuran-3-carbonitrile

Chemical Property:

XLogP3:1.8
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:1
Exact Mass:186.079312947
Heavy Atom Count:14
Complexity:294

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(C(=C(O1)N)C#N)C2=CC=CC=C2

Technology Process of 2-Amino-4-phenyl-4,5-dihydrofuran-3-carbonitrile

There total 5 articles about 2-Amino-4-phenyl-4,5-dihydrofuran-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 2-(2-hydroxy-1-phenylethyl)malononitrile

: 59790-95-3
2-amino-4,5-dihydro-4-phenyl-3-furancarbonitrile

Guidance literature:: With silica gel; In hexane; ethyl acetate;
DOI:10.1002/anie.201803220

Reference yield: 60.0%

: 109-77-3
malononitrile

: 1674-30-2
1-phenyl-2-chloroethanol

: 22109-04-2
2-amino-3-cyano-5-phenyl-4,5-dihydrofuran

: 59790-95-3
2-amino-3-cyano-4-phenyl-4,5-dihydrofuran

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide;

Reference yield:

: 100-52-7
benzaldehyde

: 59790-95-3
2-amino-4,5-dihydro-4-phenyl-3-furancarbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine / ethanol / Reflux; Inert atmosphere

2: 9-(2-mesityl)-10-methylacridinium perchlorate; water / acetonitrile / 20 - 30 °C / Inert atmosphere; Irradiation

3: triethylamine / acetonitrile / 4 h / 20 °C / Inert atmosphere

With piperidine; water; triethylamine; 9-(2-mesityl)-10-methylacridinium perchlorate; In ethanol; acetonitrile; 3: |Giese Free Radical Synthesis;
DOI:10.1039/c9cc08781h