4-Methoxy-2-nitro-N,N-dimethylaniline

Base Information

• Chemical Name: 4-Methoxy-2-nitro-N,N-dimethylaniline
• CAS No.: 60049-83-4
• Molecular Formula: C9H12N2O3
• Molecular Weight: 196.206
• DSSTox Substance ID: DTXSID70437480
• Wikidata: Q82252975
• Mol file: 60049-83-4.mol

Synonyms:60049-83-4;4-Methoxy-2-nitro-N,N-dimethylaniline;Benzenamine, 4-methoxy-N,N-dimethyl-2-nitro-;4-METHOXY-N,N-DIMETHYL-2-NITROANILINE;SCHEMBL3991397;DTXSID70437480;KSVTUPVNIVTQBR-UHFFFAOYSA-N;AKOS005147739;(4-methoxy-2-nitrophenyl)dimethylamine

Chemical Property of 4-Methoxy-2-nitro-N,N-dimethylaniline

Chemical Property:

• PSA: 58.29000
• LogP: 2.19260
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 196.08479225
• Heavy Atom Count: 14
• Complexity: 203

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C1=C(C=C(C=C1)OC)[N+](=O)[O-]

Technology Process of 4-Methoxy-2-nitro-N,N-dimethylaniline

There total 13 articles about 4-Methoxy-2-nitro-N,N-dimethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

4-methoxy-N,N-dimethylanilne (701-56-4) → 4-Methoxy-2-nitro-N,N-dimethylbenzeneamine (60049-83-4)

Guidance literature:

With cerium (IV) sulfate; sodium nitrite; In water; at 20 ℃; for 1h;

DOI:10.1080/00397910701484025

Reference yield: 63.0%

dimethyl sulfate (77-78-1) + 4-methoxy-2-nitroaniline (96-96-8) → 4-Methoxy-2-nitro-N,N-dimethylbenzeneamine (60049-83-4)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; for 6h; Heating / reflux;

Reference yield: 15.4%

4-methoxy-N,N-dimethylanilne (701-56-4) → N-methyl-N-nitroso-p-anisidine (940-11-4) + 4-Methoxy-2-nitro-N,N-dimethylbenzeneamine (60049-83-4)

Guidance literature:

With 3,3-Dibenzyl-1-(4-tolyl)-1-nitrosourea; In tetrachloromethane; at 20 ℃; for 1.3h;

DOI:10.1248/cpb.42.1760

upstream raw materials:

4-methoxy-N,N-dimethylanilne

dimethyl amine

2-chloro-5-methoxynitrobenzene

n-Butyl nitrite

Downstream raw materials:

4-methoxy-N¹,N¹-dimethyl-o-phenylenediamine

1-(2-Dimethylamino-5-methoxy-phenyl)-3-pentyl-urea

N-(2-dimethylamino-5-methoxyphenyl)acetamide