5-Chloro-2-(phenoxymethyl)benzoic acid

Base Information

Chemical Name:5-Chloro-2-(phenoxymethyl)benzoic acid
CAS No.:60086-32-0
Molecular Formula:C₁₄H₁₁ClO₃
Molecular Weight:262.693
Hs Code.:
DSSTox Substance ID:DTXSID00605958
Wikidata:Q82504444

Synonyms:5-Chloro-2-(phenoxymethyl)benzoic acid;60086-32-0;2-phenoxymethyl-5-chlorobenzoic acid;SCHEMBL11574914;DTXSID00605958;KTZQMOQHSQRAJH-UHFFFAOYSA-N

Suppliers and Price of 5-Chloro-2-(phenoxymethyl)benzoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 5-Chloro-2-(phenoxymethyl)benzoic acid

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:262.0396719
Heavy Atom Count:18
Complexity:276

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C=C1)OCC2=C(C=C(C=C2)Cl)C(=O)O

Technology Process of 5-Chloro-2-(phenoxymethyl)benzoic acid

There total 6 articles about 5-Chloro-2-(phenoxymethyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 19641-29-3
6-chlorophthalide

: 108-95-2,27073-41-2
phenol

: 60086-32-0
2-phenoxymethyl-5-chlorobenzoic acid

Guidance literature:: In N-methyl-acetamide;

Reference yield:

: 56427-54-4
5-chloro-2-methyl-benzoic acid ethyl ester

: 60086-32-0
2-phenoxymethyl-5-chlorobenzoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3.5 h / Reflux

2: sodium ethanolate / ethanol / 6.5 h / Reflux

3: sodium hydroxide; water / ethanol / 1 h / Reflux

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); water; sodium ethanolate; sodium hydroxide; In tetrachloromethane; ethanol;
DOI:10.1016/j.phrs.2016.09.042

Reference yield:

: 7499-06-1
5-chloro-2-methylbenzoic acid

: 60086-32-0
2-phenoxymethyl-5-chlorobenzoic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / N,N-dimethyl-formamide / 24 h / 20 °C

2: N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile) / tetrachloromethane / 3.5 h / Reflux

3: sodium ethanolate / ethanol / 6.5 h / Reflux

4: sodium hydroxide; water / ethanol / 1 h / Reflux

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); water; sodium ethanolate; potassium carbonate; sodium hydroxide; In tetrachloromethane; ethanol; N,N-dimethyl-formamide;
DOI:10.1016/j.phrs.2016.09.042