N-(3-Hydroxy-3,3-diphenylpropyl)benzamide

Base Information

• Chemical Name: N-(3-Hydroxy-3,3-diphenylpropyl)benzamide
• CAS No.: 60181-44-4
• Molecular Formula: C22H21NO2
• Molecular Weight: 331.414
• DSSTox Substance ID: DTXSID80556116
• Wikidata: Q82437595
• Mol file: 60181-44-4.mol

Synonyms:60181-44-4;N-(3-Hydroxy-3,3-diphenylpropyl)benzamide;SCHEMBL11628852;DTXSID80556116;MUVNHRFYPHBBSI-UHFFFAOYSA-N;N-benzoyl-3-hydroxy-3,3-diphenylpropylamine

Chemical Property of N-(3-Hydroxy-3,3-diphenylpropyl)benzamide

Chemical Property:

• XLogP3: 3.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 6
• Exact Mass: 331.157228913
• Heavy Atom Count: 25
• Complexity: 386

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)NCCC(C2=CC=CC=C2)(C3=CC=CC=C3)O

Technology Process of N-(3-Hydroxy-3,3-diphenylpropyl)benzamide

There total 6 articles about N-(3-Hydroxy-3,3-diphenylpropyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-hydroxy-3,3-diphenyl-propylamine (4320-44-9) + benzoyl chloride (98-88-4) → N-(3-hydroxy-3,3-diphenyl-propyl)-benzamide (60181-44-4)

Guidance literature:

With pyridine; sodium hydroxide; In dichloromethane; water;

Reference yield:

N-(2-chloro-ethyl)-benzamide (26385-07-9) → N-(3-hydroxy-3,3-diphenyl-propyl)-benzamide (60181-44-4)

Guidance literature:

Multi-step reaction with 2 steps

1: n-buthyl-lithium, lithium naphthalenide / tetrahydrofuran; diethyl ether / 4 h / -78 °C

2: H₂O / -78 - 20 °C

With n-butyllithium; water; naphthalen-1-yl-lithium; In tetrahydrofuran; diethyl ether;

DOI:10.1016/S0040-4020(01)80078-8

Reference yield:

benzophenone (119-61-9) + N-lithio-N-(2-lithioethyl)benzamide (150932-87-9) → N-(3-hydroxy-3,3-diphenyl-propyl)-benzamide (60181-44-4)

Guidance literature:

With water; at -78 - 20 ℃; Yield given;

DOI:10.1016/S0040-4020(01)80078-8

upstream raw materials:

benzophenone

N-(2-chloro-ethyl)-benzamide

N-lithio-N-(2-lithioethyl)benzamide

3-hydroxy-3,3-diphenyl-propylamine

Downstream raw materials:

N-benzoyl-3,3-diphenylprop-2-en-1-ylamine

3-benzylamino-1,1-diphenyl-propan-1-ol

4-benzyl-7,7-diphenyl-[1,4]oxazepan-3-one

N-benzyl-n-chloroacetyl-3-hydroxy-3,3-diphenylpropylamine