4-[(2-Nitrophenyl)methyl]pyridine

Base Information

Chemical Name:4-[(2-Nitrophenyl)methyl]pyridine
CAS No.:60288-89-3
Molecular Formula:C12H10N2O2
Molecular Weight:214.224
Hs Code.:
DSSTox Substance ID:DTXSID90607547
Nikkaji Number:J2.132.511B
Wikidata:Q82506583

Synonyms:4-[(2-Nitrophenyl)methyl]pyridine;60288-89-3;SCHEMBL3271043;DTXSID90607547

Suppliers and Price of 4-[(2-Nitrophenyl)methyl]pyridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of 4-[(2-Nitrophenyl)methyl]pyridine

Chemical Property:

XLogP3:2.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:214.074227566
Heavy Atom Count:16
Complexity:234

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=C(C(=C1)CC2=CC=NC=C2)[N+](=O)[O-]

Technology Process of 4-[(2-Nitrophenyl)methyl]pyridine

There total 6 articles about 4-[(2-Nitrophenyl)methyl]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: 882525-05-5
4-(diisopropoxy-phosphoryl)-4-[hydroxy-(2-nitro-phenyl)-methyl]-4H-pyridine-1-carboxylic acid ethyl ester

: 60288-89-3
4-(2-nitrobenzyl)pyridine

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran;
DOI:10.3987/COM-05-S(T)49

Reference yield: 37.0%

: 10445-91-7
4-(Chloromethyl)pyridine

: 98-95-3,26969-40-4
nitrobenzene

: 1083-48-3
4-Nitrobenzylpyridin

: 60288-89-3
4-(2-nitrobenzyl)pyridine

Guidance literature:: With potassium tert-butylate; In dimethyl sulfoxide; at 20 ℃; for 1h;
DOI:10.1002/ejoc.200300806

Reference yield:

: 110-86-1
pyridine

: 60288-89-3
4-(2-nitrobenzyl)pyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: acetonitrile / 0.5 h / 0 °C

1.2: 51 percent / NaI / acetonitrile / 2 h / 50 °C

2.1: diisopropylamine; n-BuLi / tetrahydrofuran; hexane / 1 h / -78 °C

2.2: 65 percent / tetrahydrofuran; hexane / -78 °C

3.1: 68 percent / tert-BuOK / tetrahydrofuran

With n-butyllithium; potassium tert-butylate; diisopropylamine; In tetrahydrofuran; hexane; acetonitrile;
DOI:10.3987/COM-05-S(T)49