Cyanoacetic acid trimethylsilyl ester

Base Information

• Chemical Name: Cyanoacetic acid trimethylsilyl ester
• CAS No.: 60511-70-8
• Molecular Formula: C6H11NO2Si
• Molecular Weight: 157.24300
• Mol file: 60511-70-8.mol

Synonyms:Trimethylsilylcyanoacetat;Cyanessigsaeure-trimethylsilylester;Acetic acid,cyano-,trimethylsilyl ester;trimethylsilyl cyanoacetate;

Chemical Property of Cyanoacetic acid trimethylsilyl ester

Chemical Property:

• PSA: 50.09000
• LogP: 1.27818

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyanoacetic acid trimethylsilyl ester

There total 3 articles about Cyanoacetic acid trimethylsilyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

chloro-trimethyl-silane (75-77-4) + cyanoacetic acid (372-09-8) → Cyanessigsaeure-trimethylsilylester (60511-70-8)

Guidance literature:

In 1,2-dichloro-ethane; at 65 ℃; for 16h;

DOI:10.1055/s-1980-29144

Reference yield:

cyanoacetic acid (372-09-8) → Cyanessigsaeure-trimethylsilylester (60511-70-8)

Guidance literature:

With chloro-trimethyl-silane; ammonium chloride; 1,1,1,3,3,3-hexamethyl-disilazane; In tetrahydrofuran;

Reference yield:

→ Cyanessigsaeure-trimethylsilylester (60511-70-8)

Guidance literature:

Cyanessigsaeure, Trimethylsilylchlorid/Et3N;

upstream raw materials:

chloro-trimethyl-silane

cyanoacetic acid

Refernces

• 1、 Hergott, Hans Herbert,Simchen, Gerhard. "Eine einfache Synthese von Trichloromethyltrimethylsilan und Carbonsaeure-trimethylsilylestern". . p. 626 - 627. Retrieved 2007/10/02.