7-(benzyloxy)-2,4-dichloro-6-methoxyquinazoline

Base Information

• Chemical Name: 7-(benzyloxy)-2,4-dichloro-6-methoxyquinazoline
• CAS No.: 60771-18-8
• Molecular Formula: C16H12Cl2N2O2
• Molecular Weight: 335.189
• Hs Code.: 2933990090
• Mol file: 60771-18-8.mol

Synonyms:

Chemical Property of 7-(benzyloxy)-2,4-dichloro-6-methoxyquinazoline

Chemical Property:

• Boiling Point: 447.6±45.0 °C(Predicted)
• PKA: -0.54±0.30(Predicted)
• PSA: 44.24000
• Density: 1.381±0.06 g/cm3(Predicted)
• LogP: 4.52420
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

7-(Benzyloxy)-2,4-dichloro-6-methoxyquinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-(benzyloxy)-2,4-dichloro-6-methoxyquinazoline

There total 17 articles about 7-(benzyloxy)-2,4-dichloro-6-methoxyquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

7-(benzyloxy)-6-methoxyquinazoline-2,4(1H,3H)-dione (60548-00-7) → 7-(benzyloxy)-2,4-dichloro-6-methoxyquinazoline (60771-18-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; trichlorophosphate; In acetonitrile; for 6h; Reflux;

DOI:10.1039/c7md00052a

Reference yield: 61.0%

7-(benzyloxy)-6-methoxyquinazoline-2,4-diol → 7-(benzyloxy)-2,4-dichloro-6-methoxyquinazoline (60771-18-8)

Guidance literature:

With N,N-diethylaniline; trichlorophosphate; at 0 - 120 ℃; for 7h;

Reference yield:

2-amino-4-(benzyloxy)-5-methoxybenzonitrile (385785-02-4) + methyl chloroformate (79-22-1) → 7-(benzyloxy)-2,4-dichloro-6-methoxyquinazoline (60771-18-8)

Guidance literature:

2-amino-4-(benzyloxy)-5-methoxybenzonitrile; methyl chloroformate; With N-ethyl-N,N-diisopropylamine; In dichloromethane; N,N-dimethyl-formamide; at 0 - 20 ℃;

With dihydrogen peroxide; sodium hydroxide; In ethanol;

With N,N-diethylaniline; trichlorophosphate; Reflux;

upstream raw materials:

5-amino-2-methoxyphenol

3-benzyloxy-4-methoxybenzeneamine

tert-butyl N-(3-hydroxy-4-methoxyphenyl)carbamate

7-(benzyloxy)-6-methoxyquinazoline-2,4(1H,3H)-dione

Refernces

• 1、 -. "Cellular Compositions Used To Restore Stem Cell or Progenitor Cell Function and Methods Related Thereto". Paragraph 0137. . Retrieved 2017/07/01.
• 2、 -. "Compounds and compositions used to epigenetically transform cells and methods related thereto". Page/Page column 14. . Retrieved 2016/10/24.