N-[1-[(2R,4S,5R)-4-hydroxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

Base Information

Chemical Name:N-[1-[(2R,4S,5R)-4-hydroxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide
CAS No.:60920-99-2
Molecular Formula:C36H33N3O6
Molecular Weight:603.675
Hs Code.:
DSSTox Substance ID:DTXSID10384363

Synonyms:60920-99-2;N-[1-[(2R,4S,5R)-4-hydroxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide;AC1MCXSP;DTXSID10384363;AKOS024422592;N-(1-((2R,4S,5R)-4-HYDROXY-5-(((4-METHOXYPHENYL)DIPHENYLMETHOXY)METHYL)TETRAHYDROFURAN-2-YL)-2-OXO-1,2-DIHYDROPYRIMIDIN-4-YL)BENZAMIDE

Suppliers and Price of N-[1-[(2R,4S,5R)-4-hydroxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of N-[1-[(2R,4S,5R)-4-hydroxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

Chemical Property:

PSA：115.40000
LogP:4.99550
XLogP3:5.3
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:10
Exact Mass:603.23693578
Heavy Atom Count:45
Complexity:1040

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)OCC4C(CC(O4)N5C=CC(=NC5=O)NC(=O)C6=CC=CC=C6)O
Isomeric SMILES:COC1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC[C@@H]4[C@H](C[C@@H](O4)N5C=CC(=NC5=O)NC(=O)C6=CC=CC=C6)O

Technology Process of N-[1-[(2R,4S,5R)-4-hydroxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide

There total 8 articles about N-[1-[(2R,4S,5R)-4-hydroxy-5-[[(4-methoxyphenyl)-diphenylmethoxy]methyl]oxolan-2-yl]-2-oxopyrimidin-4-yl]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 4836-13-9
N₄-benzoyl-2'-deoxycytidine

: 14470-28-1
mono-4-methoxytrityl chloride

: 60920-99-2
N⁴-Benzoyl-5'-O-monomethoxytrityl-2'-deoxycytidine

Guidance literature:: With pyridine; for 20h; Ambient temperature;
DOI:10.1055/s-1984-31040

Reference yield:

: 3992-42-5
2'-deoxycytidine monohydrochloride

: 60920-99-2
N⁴-Benzoyl-5'-O-monomethoxytrityl-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) pyridine, Et₃N, 2.) 2N NaOH / 1.) RT, 1 h, 2.) MeOH, THF, 0 deg C, 15 min

2: pyridine / 3 h / 25 °C

With pyridine; sodium hydroxide; triethylamine;
DOI:10.1248/cpb.29.3274

Reference yield:

: 951-77-9
2'-Deoxycytidine

: 60920-99-2
N⁴-Benzoyl-5'-O-monomethoxytrityl-2'-deoxycytidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) pyridine, 2.) aq. NaOH / 1.) 3 h, room temp., 2.) THF, MeOH, H₂O, 15 min, 0 deg C

2: 88 percent / pyridine / 20 h / Ambient temperature

With pyridine; sodium hydroxide;
DOI:10.1055/s-1984-31040