Methyl 4-(benzyloxy)-1H-indole-6-carboxylate

Base Information

Chemical Name:Methyl 4-(benzyloxy)-1H-indole-6-carboxylate
CAS No.:61545-36-6
Molecular Formula:C17H15NO3
Molecular Weight:281.311
Hs Code.:2933990090
DSSTox Substance ID:DTXSID10444491
Wikidata:Q82262639
Mol file:61545-36-6.mol

Synonyms:Methyl 4-(benzyloxy)-1H-indole-6-carboxylate;61545-36-6;Methyl 4-phenylmethoxy-1H-indole-6-carboxylate;4-Benzloxy-6-indole carboxylic acid methyl ester;SCHEMBL6868530;DTXSID10444491;MFCD11110567;AKOS022172893;Methyl 4-Benzyloxy-indole-6-carboxylate;CS-0038299;FT-0708459;Methyl4-(benzyloxy)-1H-indole-6-carboxylate;4-benzyloxyindole-6-carboxylic acid methyl ester;Methyl 4- (benzyloxy) -1H-indole-6-carboxylate;A868686;A1-51064

Suppliers and Price of Methyl 4-(benzyloxy)-1H-indole-6-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Methyl4-(benzyloxy)-1H-indole-6-carboxylate 95+%
250mg
$ 198.00

Crysdot
Methyl4-(benzyloxy)-1H-indole-6-carboxylate 95+%
1g
$ 495.00

Chemenu
Methyl4-(benzyloxy)-1H-indole-6-carboxylate 95%
1g
$ 463.00

Chemenu
Methyl4-(benzyloxy)-1H-indole-6-carboxylate 95%
250mg
$ 202.00

Alichem
Methyl4-Benzyloxy-indole-6-carboxylate
1g
$ 1819.80

Alichem
Methyl4-Benzyloxy-indole-6-carboxylate
500mg
$ 989.80

Alichem
Methyl4-Benzyloxy-indole-6-carboxylate
250mg
$ 741.20

AK Scientific
Methyl4-Benzyloxy-indole-6-carboxylate
1g
$ 654.80

Total 13 raw suppliers

Chemical Property of Methyl 4-(benzyloxy)-1H-indole-6-carboxylate

Chemical Property:

PSA：51.32000
LogP:3.53350
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:3.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:5
Exact Mass:281.10519334
Heavy Atom Count:21
Complexity:354

Purity/Quality:

97% ^*data from raw suppliers

Methyl4-(benzyloxy)-1H-indole-6-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=CC2=C(C=CN2)C(=C1)OCC3=CC=CC=C3

Technology Process of Methyl 4-(benzyloxy)-1H-indole-6-carboxylate

There total 5 articles about Methyl 4-(benzyloxy)-1H-indole-6-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

active charcoal: active charcoal

: 100-44-7
benzyl chloride

: 77140-48-8
4-hydroxy-1H-indole-6-carboxylic acid methyl ester

: 61545-36-6
methyl 4-(benzyloxy)-1H-indole-6-carboxylate

Guidance literature:: With potassium carbonate; In water; N,N-dimethyl-formamide;

Reference yield:

: 125229-13-2
3-hydroxy-4-methyl-5-nitrobenzoic acid methyl ester

: 61545-36-6
methyl 4-(benzyloxy)-1H-indole-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / K₂CO₃ / dimethylformamide / 5.5 h / 100 °C

2: 1.) pyrrolidine, 2.) Raney nickel, hydrazine hydrate / 1) DMF, 110 deg C, 3.5 h; 2) water, THF, CH₃OH, rt --> 43 deg C

With pyrrolidine; nickel; potassium carbonate; hydrazine hydrate; In N,N-dimethyl-formamide;
DOI:10.1021/jo961992n

Reference yield:

: 100-44-7
benzyl chloride

: 61545-36-6
methyl 4-(benzyloxy)-1H-indole-6-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / K₂CO₃ / dimethylformamide / 5.5 h / 100 °C

2: 1.) pyrrolidine, 2.) Raney nickel, hydrazine hydrate / 1) DMF, 110 deg C, 3.5 h; 2) water, THF, CH₃OH, rt --> 43 deg C

With pyrrolidine; nickel; potassium carbonate; hydrazine hydrate; In N,N-dimethyl-formamide;
DOI:10.1021/jo961992n