(2R,3S)-3-(4-Benzyloxy-3-formyl-6-methoxycarbonyl-indol-1-ylmethyl)-aziridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Base Information

Chemical Name:(2R,3S)-3-(4-Benzyloxy-3-formyl-6-methoxycarbonyl-indol-1-ylmethyl)-aziridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester
CAS No.:187682-28-6
Molecular Formula:C₂₈H₃₀N₂O₈
Molecular Weight:522.555
Hs Code.:

Synonyms:(2R,3S)-3-(4-Benzyloxy-3-formyl-6-methoxycarbonyl-indol-1-ylmethyl)-aziridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

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Chemical Property of (2R,3S)-3-(4-Benzyloxy-3-formyl-6-methoxycarbonyl-indol-1-ylmethyl)-aziridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

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Technology Process of (2R,3S)-3-(4-Benzyloxy-3-formyl-6-methoxycarbonyl-indol-1-ylmethyl)-aziridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

There total 6 articles about (2R,3S)-3-(4-Benzyloxy-3-formyl-6-methoxycarbonyl-indol-1-ylmethyl)-aziridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 125229-13-2
3-hydroxy-4-methyl-5-nitrobenzoic acid methyl ester

: 187682-28-6
(2R,3S)-3-(4-Benzyloxy-3-formyl-6-methoxycarbonyl-indol-1-ylmethyl)-aziridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / K₂CO₃ / dimethylformamide / 5.5 h / 100 °C

2: 1.) pyrrolidine, 2.) Raney nickel, hydrazine hydrate / 1) DMF, 110 deg C, 3.5 h; 2) water, THF, CH₃OH, rt --> 43 deg C

3: 92 percent / POCl₃ / tetrahydrofuran / 3 h / Ambient temperature

4: 1.) NaN(TMS)2 / 1) THF, rt, 1.5 h; 2) THF, CH₂Cl₂, -30 deg C, 1 h

With pyrrolidine; sodium hexamethyldisilazane; nickel; potassium carbonate; hydrazine hydrate; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo961992n

Reference yield:

: 61545-36-6
methyl 4-(benzyloxy)-1H-indole-6-carboxylate

: 187682-28-6
(2R,3S)-3-(4-Benzyloxy-3-formyl-6-methoxycarbonyl-indol-1-ylmethyl)-aziridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 92 percent / POCl₃ / tetrahydrofuran / 3 h / Ambient temperature

2: 1.) NaN(TMS)2 / 1) THF, rt, 1.5 h; 2) THF, CH₂Cl₂, -30 deg C, 1 h

With sodium hexamethyldisilazane; trichlorophosphate; In tetrahydrofuran;
DOI:10.1021/jo961992n

Reference yield:

: 100-44-7
benzyl chloride

: 187682-28-6
(2R,3S)-3-(4-Benzyloxy-3-formyl-6-methoxycarbonyl-indol-1-ylmethyl)-aziridine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / K₂CO₃ / dimethylformamide / 5.5 h / 100 °C

2: 1.) pyrrolidine, 2.) Raney nickel, hydrazine hydrate / 1) DMF, 110 deg C, 3.5 h; 2) water, THF, CH₃OH, rt --> 43 deg C

3: 92 percent / POCl₃ / tetrahydrofuran / 3 h / Ambient temperature

4: 1.) NaN(TMS)2 / 1) THF, rt, 1.5 h; 2) THF, CH₂Cl₂, -30 deg C, 1 h

With pyrrolidine; sodium hexamethyldisilazane; nickel; potassium carbonate; hydrazine hydrate; trichlorophosphate; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jo961992n