2H-Benzimidazol-2-one, 1,3-dihydro-1-(1-(2-(3,4-dihydroxyphenyl)-2-hydroxyethyl)-4-piperidinyl)-

Base Information

• Chemical Name: 2H-Benzimidazol-2-one, 1,3-dihydro-1-(1-(2-(3,4-dihydroxyphenyl)-2-hydroxyethyl)-4-piperidinyl)-
• CAS No.: 74405-95-1
• Molecular Formula: C₂₀H₂₃N₃O₄
• Molecular Weight: 369.42
• DSSTox Substance ID: DTXSID60995923

Synonyms:((Dihydroxy-3,4 phenyl)-2 hydroxy-2) ethyl-1 (oxo-2 benzimidazolinyl-1)-4 piperidine [French];2H-Benzimidazol-2-one, 1,3-dihydro-1-(1-(2-(3,4-dihydroxyphenyl)-2-hydroxyethyl)-4-piperidinyl)-;74405-95-1;((Dihydroxy-3,4 phenyl)-2 hydroxy-2) ethyl-1 (oxo-2 benzimidazolinyl-1)-4 piperidine;DTXSID60995923;LS-33359;4-{1-Hydroxy-2-[4-(2-hydroxy-1H-benzimidazol-1-yl)piperidin-1-yl]ethyl}benzene-1,2-diol

Chemical Property of 2H-Benzimidazol-2-one, 1,3-dihydro-1-(1-(2-(3,4-dihydroxyphenyl)-2-hydroxyethyl)-4-piperidinyl)-

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Density: 1.385g/cm³
• XLogP3: 2.1
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 4
• Exact Mass: 369.16885622
• Heavy Atom Count: 27
• Complexity: 525

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCC1N2C3=CC=CC=C3NC2=O)CC(C4=CC(=C(C=C4)O)O)O

Technology Process of 2H-Benzimidazol-2-one, 1,3-dihydro-1-(1-(2-(3,4-dihydroxyphenyl)-2-hydroxyethyl)-4-piperidinyl)-

There total 3 articles about 2H-Benzimidazol-2-one, 1,3-dihydro-1-(1-(2-(3,4-dihydroxyphenyl)-2-hydroxyethyl)-4-piperidinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

chloroethane (75-00-3) + 2-chloro-3',4'-dihydroxyacetophenone (99-40-1) + 4-(2-keto-1-benzimidazolinyl)piperidine (20662-53-7) → 1-(3,4-dihydroxy phenacyl)-4-(2-oxobenzimidazolin-1-yl)piperidine hydrochloride + 1-[2-(3,4-dihydroxyphenyl)-2-hydroxy]ethyl-4-(2-oxo benzimidazolin-1-yl)piperidine (74405-95-1)

Guidance literature:

With sodium iodide; In methanol; sodium carbonate; 2,4-dimethylpentan-3-one;

Reference yield:

methanesulfonic acid (75-75-2,98527-29-8) + 2-chloro-1-(3,4-dihydroxy-phenyl)-ethanol (5530-29-0) + 2-chloro-3',4'-dihydroxyacetophenone (99-40-1) + 4-(2-keto-1-benzimidazolinyl)piperidine (20662-53-7) → 1-[2-(3,4-dihydroxyphenyl)-2-hydroxy]ethyl-4-(2-oxo benzimidazolin-1-yl)piperidine (74405-95-1)

Guidance literature:

In water; potassium carbonate; butan-1-ol;

Reference yield:

methanesulfonic acid (75-75-2,98527-29-8) + 3,4-dibenzyloxyphenol glyoxal + 4-(2-keto-1-benzimidazolinyl)piperidine (20662-53-7) → 1-[2-(3,4-dihydroxyphenyl)-2-hydroxy]ethyl-4-(2-oxo benzimidazolin-1-yl)piperidine (74405-95-1)

Guidance literature:

In palladised charcoal; ethanol; water; palladium;

upstream raw materials:

chloroethane

2-chloro-3',4'-dihydroxyacetophenone

4-(2-keto-1-benzimidazolinyl)piperidine

methanesulfonic acid

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