Propanoic acid, 2,2-dimethyl-, (1S,2E)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methyl-1-[(1R,2S,5R)- 5-methyl-2-(1-methylethyl)cyclohexyl]-2-butenyl ester

Base Information

Chemical Name:Propanoic acid, 2,2-dimethyl-, (1S,2E)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methyl-1-[(1R,2S,5R)- 5-methyl-2-(1-methylethyl)cyclohexyl]-2-butenyl ester
CAS No.:616866-94-5
Molecular Formula:C26H50O3Si
Molecular Weight:438.767
Hs Code.:

Propanoic acid, 2,2-dimethyl-,
(1S,2E)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methyl-1-[(1R,2S,5R)-
5-methyl-2-(1-methylethyl)cyclohexyl]-2-butenyl ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Propanoic acid, 2,2-dimethyl-, (1S,2E)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methyl-1-[(1R,2S,5R)- 5-methyl-2-(1-methylethyl)cyclohexyl]-2-butenyl ester

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Technology Process of Propanoic acid, 2,2-dimethyl-, (1S,2E)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methyl-1-[(1R,2S,5R)- 5-methyl-2-(1-methylethyl)cyclohexyl]-2-butenyl ester

There total 7 articles about Propanoic acid, 2,2-dimethyl-, (1S,2E)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-3-methyl-1-[(1R,2S,5R)- 5-methyl-2-(1-methylethyl)cyclohexyl]-2-butenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 3282-30-2
pivaloyl chloride

: 616866-93-4
(E)-(S)-4-(tert-Butyl-dimethyl-silanyloxy)-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-3-methyl-but-2-en-1-ol

: 616866-94-5
2,2-Dimethyl-propionic acid (E)-(S)-4-(tert-butyl-dimethyl-silanyloxy)-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-3-methyl-but-2-enyl ester

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃; for 96h;
DOI:10.1021/ja046084j

Reference yield:

: 80434-59-9,485843-44-5,796865-68-4
(1R,2S,5R)-2-isopropyl-5-methylcyclohexanecarboxaldehyde

: 616866-94-5
2,2-Dimethyl-propionic acid (E)-(S)-4-(tert-butyl-dimethyl-silanyloxy)-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-3-methyl-but-2-enyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis(cyclopentadienyl) zirconium / CH₂Cl₂ / 0.17 h

1.2: CH₂Cl₂ / 12 h / 20 °C

1.3: 100 percent / tetrahydrofuran; CH₂Cl₂ / 12 h / -78 - 20 °C

2.1: 6.96 g / imidazole / CH₂Cl₂ / 3 h / 20 °C

3.1: 95 percent / triethylamine; dimethylaminopyridine / CH₂Cl₂ / 96 h / 0 - 20 °C

With 1H-imidazole; dmap; bis(cyclopentadienyl)dihydrozirconium; triethylamine; In dichloromethane;
DOI:10.1021/ja046084j

Reference yield:

: (E)-1-((1R,2S,5R)-2-Isopropyl-5-methyl-cyclohexyl)-3-methyl-but-2-ene-1,4-diol

: 616866-94-5
2,2-Dimethyl-propionic acid (E)-(S)-4-(tert-butyl-dimethyl-silanyloxy)-1-((1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl)-3-methyl-but-2-enyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 6.96 g / imidazole / CH₂Cl₂ / 3 h / 20 °C

2: 95 percent / triethylamine; dimethylaminopyridine / CH₂Cl₂ / 96 h / 0 - 20 °C

With 1H-imidazole; dmap; triethylamine; In dichloromethane;
DOI:10.1021/ja046084j