Pregnenolone methyl ether

Base Information

Chemical Name:Pregnenolone methyl ether
CAS No.:511-26-2
Molecular Formula:C22H34 O2
Molecular Weight:330.5
Hs Code.:
NSC Number:31617
UNII:TU767RK7YN
DSSTox Substance ID:DTXSID901304765
Nikkaji Number:J6.265K
Wikipedia:3%CE%B2-Methoxypregnenolone
Wikidata:Q27290371
Mol file:511-26-2.mol

Synonyms:Pregnenolone methyl ether;511-26-2;Pregnenolone 3-methyl ether;MAP4343;MAP-4343;NSC-31617;Pregnenolone methyl ether [MI];UNII-TU767RK7YN;TU767RK7YN;3beta-Methoxy-5-pregnen-20-one;L-542856-0;1-[(3S,8S,9S,10R,13S,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone;Pregn-5-en-20-one, 3-methoxy-, (3beta)-;1-[(3S,8S,9S,10R,13R,14S,17S)-3-methoxy-10,13-dimethyl-2,3,4,7,8,9,11, 12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]ethanone;SCHEMBL2513673;DTXSID901304765;3.BETA.-METHOXYPREGNENOLONE;NSC31617;(3beta)-3-Methoxypregn-5-en-20-one;Pregn-5-en-20-one, 3.beta.-methoxy-;MS-24973;3.BETA.-METHOXY-5-PREGNEN-20-ONE;HY-107116;CS-0027351;Pregn-5-en-20-one, 3-methoxy-, (3.beta.)-;Q27290371;L 542856-0;1-[(1S,3aS,3bS,7S,9aR,9bS,11aS)-7-methoxy-9a,11a-dimethyl-1H,2H,3H,3aH,3bH,4H,6H,7H,8H,9H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthren-1-yl]ethan-1-one

Suppliers and Price of Pregnenolone methyl ether

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

ChemScene
MAP4343
25mg
$ 350.00

ChemScene
MAP4343
10mg
$ 170.00

ChemScene
MAP4343
5mg
$ 100.00

ChemScene
MAP4343
100mg
$ 900.00

American Custom Chemicals Corporation
PREGNENOLONE METHYL ETHER 95.00%
5MG
$ 499.04

Total 9 raw suppliers

Chemical Property of Pregnenolone methyl ether

Chemical Property:

Vapor Pressure:1.75E-07mmHg at 25°C
Melting Point:123.5°
Boiling Point:426.6°Cat760mmHg
Flash Point:161.3°C
PSA：26.30000
Density:1.04g/cm³
LogP:5.16940
XLogP3:4.8
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:330.255880323
Heavy Atom Count:24
Complexity:564

Purity/Quality:

99% ^*data from raw suppliers

MAP4343 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(=O)C1CCC2C1(CCC3C2CC=C4C3(CCC(C4)OC)C)C
Isomeric SMILES:CC(=O)[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CC=C4[C@@]3(CC[C@@H](C4)OC)C)C
Recent ClinicalTrials:RESIST : Administration of MAP4343 in Antidepressant Non-Responders Patients Experiencing a Major Depressive Episode

Technology Process of Pregnenolone methyl ether

There total 14 articles about Pregnenolone methyl ether which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 67-56-1
methanol

: 6885-40-1
3β-toluene-4-sulfonyloxy-pregn-5-en-20-one

: 511-26-2
pregnenolone methyl ether

Guidance literature:: for 4h; Heating / reflux;

Reference yield: 73.0%

: 145-13-1
Pregnenolone

: 74-88-4
methyl iodide

: 511-26-2
pregnenolone methyl ether

Guidance literature:: Pregnenolone; With sodium hydride; In tetrahydrofuran; paraffin oil; at 0 - 50 ℃; for 0.5h; Inert atmosphere;

methyl iodide; In tetrahydrofuran; paraffin oil; at 50 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jo5005108

Reference yield:

: methyl-(20-methyl-21ξ-phenyl-pregnadien-(5.20)-yl-(3β))-ether

: 511-26-2
pregnenolone methyl ether

Guidance literature:: With chloroform; bromine; anschliessend mit Ozon und Behandeln des Reaktionsprodukts mit Zink-Pulver und Essigsaeure;
DOI:10.1021/ja01169a063