N,2-Dimethyl-2-(4-nitrophenoxy)propanamide

Base Information

• Chemical Name: N,2-Dimethyl-2-(4-nitrophenoxy)propanamide
• CAS No.: 62100-50-9
• Molecular Formula: C11H14N2O4
• Molecular Weight: 238.243
• DSSTox Substance ID: DTXSID30488655
• Wikidata: Q82331456

Synonyms:N,2-Dimethyl-2-(4-nitrophenoxy)propanamide;62100-50-9;DTXSID30488655

Chemical Property of N,2-Dimethyl-2-(4-nitrophenoxy)propanamide

Chemical Property:

• XLogP3: 1.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 238.09535693
• Heavy Atom Count: 17
• Complexity: 290

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C(=O)NC)OC1=CC=C(C=C1)[N+](=O)[O-]

Technology Process of N,2-Dimethyl-2-(4-nitrophenoxy)propanamide

There total 2 articles about N,2-Dimethyl-2-(4-nitrophenoxy)propanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

2-Methyl-2-(4'-nitrophenoxy)-propionyl chloride (4878-29-9) + methylamine (74-89-5) → 2,N-Dimethyl-2-(4-nitro-phenoxy)-propionamide (62100-50-9)

Guidance literature:

With potassium carbonate; In chloroform; Heating;

Reference yield:

2-(4-nitrophenoxy)-2-methylpropanoic acid (17431-97-9) + methylamine (74-89-5) → 2,N-Dimethyl-2-(4-nitro-phenoxy)-propionamide (62100-50-9)

Guidance literature:

Multistep reaction; (i) SOCl₂, (ii) /BRN= 741851/, dioxane;

DOI:10.1055/s-1977-24262

Reference yield: 61.0%

2,N-Dimethyl-2-(4-nitro-phenoxy)-propionamide (62100-50-9) → 2-(4-Amino-phenoxy)-2,N-dimethyl-propionamide (110506-51-9)

Guidance literature:

With hydrazine hydrate; nickel; In ethanol; for 2h; Heating;

upstream raw materials:

2-Methyl-2-(4'-nitrophenoxy)-propionyl chloride

methylamine

2-(4-nitrophenoxy)-2-methylpropanoic acid

Downstream raw materials:

2-(4-Amino-phenoxy)-2,N-dimethyl-propionamide

2-Hydroxy-2,N-dimethyl-N-(4-nitro-phenyl)-propionamide

2-(4-Isothiocyanato-phenoxy)-2,N-dimethyl-propionamide

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