2-methyl-4-oxo-4,5,6,8-tetrahydro-3H-pyrido[3,4-d]pyrimidine-7-carboxylic acid 4-bromophenyl ester

Base Information

Chemical Name:2-methyl-4-oxo-4,5,6,8-tetrahydro-3H-pyrido[3,4-d]pyrimidine-7-carboxylic acid 4-bromophenyl ester
CAS No.:1073477-08-3
Molecular Formula:C₁₅H₁₄BrN₃O₃
Molecular Weight:364.198
Hs Code.:

Synonyms:2-methyl-4-oxo-4,5,6,8-tetrahydro-3H-pyrido[3,4-d]pyrimidine-7-carboxylic acid 4-bromophenyl ester

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Chemical Property of 2-methyl-4-oxo-4,5,6,8-tetrahydro-3H-pyrido[3,4-d]pyrimidine-7-carboxylic acid 4-bromophenyl ester

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Technology Process of 2-methyl-4-oxo-4,5,6,8-tetrahydro-3H-pyrido[3,4-d]pyrimidine-7-carboxylic acid 4-bromophenyl ester

There total 2 articles about 2-methyl-4-oxo-4,5,6,8-tetrahydro-3H-pyrido[3,4-d]pyrimidine-7-carboxylic acid 4-bromophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 62259-92-1
7-benzyl-2-methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one

: 7693-44-9
4-bromophenyl chloroformate

: 1073477-08-3
2-methyl-4-oxo-4,5,6,8-tetrahydro-3H-pyrido[3,4-d]pyrimidine-7-carboxylic acid 4-bromophenyl ester

Guidance literature:: 7-benzyl-2-methyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4(3H)-one; With hydrogen; palladium 10% on activated carbon; In methanol; acetic acid; for 16h; under 760.051 Torr;

4-bromophenyl chloroformate; With triethylamine; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 52763-21-0
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

: 1073477-08-3
2-methyl-4-oxo-4,5,6,8-tetrahydro-3H-pyrido[3,4-d]pyrimidine-7-carboxylic acid 4-bromophenyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium ethanolate / ethanol / 16 h / Heating / reflux

2.1: hydrogen / palladium 10% on activated carbon / methanol; acetic acid / 16 h / 760.05 Torr

2.2: 4 h / 20 °C

With hydrogen; sodium ethanolate; palladium 10% on activated carbon; In methanol; ethanol; acetic acid;