N-(Quinolin-4-YL)acetamide

Base Information

• Chemical Name: N-(Quinolin-4-YL)acetamide
• CAS No.: 32433-28-6
• Molecular Formula: C₁₁H₁₀N₂O
• Molecular Weight: 186.213
• Hs Code.: 2933499090
• UNII: 13PLR20HSG
• DSSTox Substance ID: DTXSID20186178
• Wikidata: Q72434153
• Mol file: 32433-28-6.mol

Synonyms:N-(QUINOLIN-4-YL)ACETAMIDE;32433-28-6;4-Acetylaminoquinoline;N-quinolin-4-ylacetamide;4-Acetamidoquinoline;13PLR20HSG;CCRIS 1689;Acetamide,N-4-quinolinyl-;Acetamide, N-4-quinolinyl-;UNII-13PLR20HSG;Oprea1_514702;N-4-QUINOLINYLACETAMIDE;SCHEMBL13113090;DTXSID20186178;AKOS015897042;SB67665;FT-0713822;L10180

Chemical Property of N-(Quinolin-4-YL)acetamide

Chemical Property:

• Vapor Pressure: 1.25E-07mmHg at 25°C
• Melting Point: 174℃
• Refractive Index: 1.5300 (estimate)
• Boiling Point: 430.9°C at 760 mmHg
• PKA: 12.94±0.43(Predicted)
• Flash Point: 214.4°C
• PSA: 45.22000
• Density: 1.242
• LogP: 1.61510
• Storage Temp.: 2-8°C
• XLogP3: 0.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 186.079312947
• Heavy Atom Count: 14
• Complexity: 217

Purity/Quality:

97% ^*data from raw suppliers

N-(Quinolin-4-yl)acetamide 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=CC=NC2=CC=CC=C21

Technology Process of N-(Quinolin-4-YL)acetamide

There total 4 articles about N-(Quinolin-4-YL)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

acetamide (60-35-5) + 4-chloroquinoline (611-35-8) → 4-Acetamino-chinolin (32433-28-6)

Guidance literature:

With potassium carbonate; for 14h; Heating;

Reference yield:

4-aminoquinoline (578-68-7) + acetic anhydride (108-24-7) → 4-Acetamino-chinolin (32433-28-6)

Guidance literature:

With acetic acid;

Reference yield:

4-acetylamino-quinoline-2-carboxylic acid (412033-08-0) → 4-Acetamino-chinolin (32433-28-6)

Guidance literature:

With paraffin; at 290 ℃;

DOI:10.1039/jr9490001803

upstream raw materials:

4-aminoquinoline

acetic anhydride

4-acetylamino-quinoline-2-carboxylic acid

acetamide