PEG10-Tos

Base Information

• Chemical Name: PEG10-Tos
• CAS No.: 62573-11-9
• Molecular Formula: C25H44O12S
• Molecular Weight: 568.683
• Mol file: 62573-11-9.mol

Synonyms:26-hydroxy-3,6,9,12,15,18,21,24-octaoxahexacosyl p-toluenesulfonate;

Chemical Property of PEG10-Tos

Chemical Property:

• PSA: 145.82000
• LogP: 1.90620
• Solubility.: Soluble in Water, DMSO, DCM, DMF

Purity/Quality:

97% ^*data from raw suppliers

PEG10-Tos 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: PEG10-Tos is a PEG linker containing a hydroxyl group with a tosyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The tosyl group is a very good leaving group for nucleophilic substitution reactions.

Technology Process of PEG10-Tos

There total 2 articles about PEG10-Tos which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

nonaethylene glycol (3386-18-3) + p-toluenesulfonyl chloride (98-59-9) → nonaethyleneglycol mono(p-toluenesulfonyl) ether (62573-11-9)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran; at 20 ℃; for 12h;

Reference yield:

ethylene glycol (107-21-1) + p-toluenesulfonyl chloride (98-59-9) → nonaethyleneglycol mono(p-toluenesulfonyl) ether (62573-11-9)

Guidance literature:

In pyridine; butanone;

Reference yield: 92.0%

nonaethyleneglycol mono(p-toluenesulfonyl) ether (62573-11-9) + 2,4-di-tert-Butylphenol (96-76-4) → nonaethylene glycol mono(2,4-bis(1,1-dimethylethyl)phenyl) ether

Guidance literature:

2,4-di-tert-Butylphenol; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 1h;

nonaethyleneglycol mono(p-toluenesulfonyl) ether; In tetrahydrofuran; mineral oil; at 20 ℃; for 24h;

upstream raw materials:

ethylene glycol

p-toluenesulfonyl chloride

nonaethylene glycol