2-(4-Chlorophenyl)-5-[[5-(4-chlorophenyl)furan-2-yl]methyl]furan

Base Information

• Chemical Name: 2-(4-Chlorophenyl)-5-[[5-(4-chlorophenyl)furan-2-yl]methyl]furan
• CAS No.: 62645-46-9
• Molecular Formula: C21H14Cl2O2
• Molecular Weight: 369.247
• DSSTox Substance ID: DTXSID90365039
• Nikkaji Number: J3.320.947I
• Wikidata: Q82149389
• Mol file: 62645-46-9.mol

Synonyms:62645-46-9;2-(4-chlorophenyl)-5-[[5-(4-chlorophenyl)furan-2-yl]methyl]furan;Bis(5-(4-chlorophenyl)furan-2-yl)methane;Furan, 2,2//'-methylenebis[5-(4-chlorophenyl)-;Furan, 2,2'-methylenebis[5-(4-chlorophenyl)-;DTXSID90365039;2,2'-Methylenebis[5-(4-chlorophenyl)furan];AH-262/31839060;Furan, 2,2/'-methylenebis[5-(4-chlorophenyl)-;2-(4-chlorophenyl)-5-{[5-(4-chlorophenyl)-2-furyl]methyl}furan

Chemical Property of 2-(4-Chlorophenyl)-5-[[5-(4-chlorophenyl)furan-2-yl]methyl]furan

Chemical Property:

• PSA: 26.28000
• LogP: 7.10420
• XLogP3: 6.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 368.0370851
• Heavy Atom Count: 25
• Complexity: 378

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC=C1C2=CC=C(O2)CC3=CC=C(O3)C4=CC=C(C=C4)Cl)Cl

Technology Process of 2-(4-Chlorophenyl)-5-[[5-(4-chlorophenyl)furan-2-yl]methyl]furan

There total 11 articles about 2-(4-Chlorophenyl)-5-[[5-(4-chlorophenyl)furan-2-yl]methyl]furan which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-(4-chlorophenyl)furan (17221-37-3) + formaldehyd (50-00-0,30525-89-4,61233-19-0) → Bis-<5-(4-Chlorphenyl)-2-furyl>-methan (62645-46-9) + 2-(p-Chlorophenyl)-5-dimethylaminomethylfuran hydrochloride (87689-38-1)

Guidance literature:

With hydrogenchloride; dimethyl amine; In i-Amyl alcohol; for 15h; Heating;

DOI:10.1007/BF00764687

Reference yield: 65.0%

(S)-3-(benzyloxy)-1-(4-chlorophenyl)-3-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)propan-1-one (1584709-62-5) → Bis-<5-(4-Chlorphenyl)-2-furyl>-methan (62645-46-9)

Guidance literature:

With trifluoroacetic acid; In tetrahydrofuran; water; at 40 - 45 ℃;

DOI:10.1002/ejoc.201301319

Reference yield: 63.0%

(S)-3-(benzyloxy)-1-(4-chlorophenyl)-3-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)propan-1-one (1584709-72-7) → Bis-<5-(4-Chlorphenyl)-2-furyl>-methan (62645-46-9)

Guidance literature:

With trifluoroacetic acid; In tetrahydrofuran; water; at 40 - 45 ℃;

DOI:10.1002/ejoc.201301319

upstream raw materials:

2-(4-chlorophenyl)furan

formaldehyd

dimethyl amine

<5-(4-Chlorphenyl)-2-furylmethyl>-methyl-(1-methyl-2-phenyl-ethyl)-amin