(S)-glycolic acid, compound with (R)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline (1:1)

Base Information

• Chemical Name: (S)-glycolic acid, compound with (R)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline (1:1)
• CAS No.: 94992-57-1
• Molecular Formula: C₈H₈O₃*C₁₇H₂₃NO
• Molecular Weight: 409.525
• Mol file: 94992-57-1.mol

Synonyms:

Chemical Property of (S)-glycolic acid, compound with (R)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline (1:1)

Chemical Property:

• Vapor Pressure: 1.16E-12mmHg at 25°C
• Boiling Point: 543.9°Cat760mmHg
• Flash Point: 282.7°C
• Density: g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (S)-glycolic acid, compound with (R)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline (1:1)

There total 2 articles about (S)-glycolic acid, compound with (R)-1,2,3,4,5,6,7,8-octahydro-1-[(4-methoxyphenyl)methyl]isoquinoline (1:1) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-Methoxyphenylacetic acid (104-01-8) + (S)-Mandelic acid (17199-29-0) + 2-(1-cyclohexenyl)ethylamine (3399-73-3) → (R)-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline L-mandelate (94992-57-1,97232-75-2) + (S)-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline L-mandelate (94992-57-1,97232-75-2)

Guidance literature:

4-Methoxyphenylacetic acid; 2-(1-cyclohexenyl)ethylamine; In 5,5-dimethyl-1,3-cyclohexadiene; at 70 - 80 ℃; Dean-Stark;

With trichlorophosphate; In 5,5-dimethyl-1,3-cyclohexadiene; at 50 - 110 ℃; for 3.16667h;

(S)-Mandelic acid; Further stages;

Reference yield:

4-Methoxyphenylacetic acid (104-01-8) + (S)-Mandelic acid (17199-29-0) + 2-(1-cyclohexenyl)ethylamine (3399-73-3) → (R)-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline L-mandelate (94992-57-1,97232-75-2) + (S)-1-(4-methoxybenzyl)-1,2,3,4,5,6,7,8-octahydroisoquinoline L-mandelate (94992-57-1,97232-75-2)

Guidance literature:

4-Methoxyphenylacetic acid; 2-(1-cyclohexenyl)ethylamine; In 5,5-dimethyl-1,3-cyclohexadiene; at 70 - 80 ℃; Dean-Stark;

With trichlorophosphate; In 5,5-dimethyl-1,3-cyclohexadiene; at 50 - 110 ℃; for 3.16667h;

(S)-Mandelic acid; Further stages;

Reference yield: 99.0%

(-)-octabase mandelate salt (94992-57-1,97232-75-2) + formic acid ethyl ester (109-94-4) → (S)-2-Formyl-1-<(4-methoxyphenyl)methyl>-1,2,3,4,5,6,7,8-octahydroispquinoline (29144-31-8)

Guidance literature:

for 48h; Reflux;

DOI:10.1021/op400309q

upstream raw materials:

4-Methoxyphenylacetic acid

(S)-Mandelic acid

2-(1-cyclohexenyl)ethylamine

Downstream raw materials:

(+)-3-methoxy-N-formylmorphinan

(+)-3-methoxymorphinan

(S)-2-Formyl-1-<(4-methoxyphenyl)methyl>-1,2,3,4,5,6,7,8-octahydroispquinoline