3399-73-3Relevant articles and documents
Pd-Catalyzed Remote Site-Selective and Stereoselective C(Alkenyl)-H Alkenylation of Unactivated Cycloalkenes
Mao, Chun-Li,Zhao, Sheng,Zang, Zhong-Lin,Xiao, Lin,Zhou, Cheng-He,He, Yun,Cai, Gui-Xin
, p. 774 - 787 (2020/01/09)
A palladium-catalyzed alkenylation involving remote δ-position C(alkenyl)-H activation of cycloalkenes reacting with electron-deficient alkenes is described. This method features excellent site selectivity and stereoselectivity to efficiently afford only E-selective highly substituted 1,3-diene derivatives with extra-ligand-free and good functional group tolerance including estrone and free N-H tryptamine under weakly alkaline conditions. Mechanistic studies suggest that picolinamide as a bidentate directing group enables the formation of unique alkenyl palladacycle intermediates.
Regioselective intramolecular Markovnikov and anti-Markovnikov hydrofunctionalization of alkenes: Via photoredox catalysis
Li, Na,Man, Yunquan,Tang, Bo,Wang, Hongyu,Wang, Kaiye,Xiang, Yanan
, p. 11426 - 11429 (2019/09/30)
Highly regioselective Markovnikov hydrofunctionalization of alkenes was successfully realized via photoredox catalysis by introducing a urea group and fine tuning the hydrogen atom transfer catalysts. The anti-Markovnikov hydroamination of alkenes was also achieved with high yields and stereoselectivities in this work.
Method for preparing 1-cyclohexene ethylamine by selective reduction
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Paragraph 0037-0042, (2018/11/27)
The invention discloses a method for preparing 1-cyclohexene ethylamine by selective reduction. The method comprises the following steps: (1) dissolving a raw material 1-cyclohexene acetonitrile in asolvent under the protection of inert gas, then slowly dropwise adding a reducing agent vitride solution at a certain temperature, and reacting at a certain temperature after dropwise adding; quenching by dropwise adding a reaction liquid into an alkali aqueous solution, extracting with an organic solvent, drying with a drying agent, carrying out desolvation with an organic phase to obtain a 1-cyclohexene ethylamine crude product; and (2) heating the 1-cyclohexene ethylamine crude product under a certain vacuum condition for distillation purification so as to obtain a 1-cyclohexene ethylaminepure product. the invention has the following advantages: 1, the vitride solution used in the method has lower toxicity and is cheaper and more easily available, thus greatly reducing raw material andoperational costs; 2, reaction steps of the method are few, the intermediate reaction is easy to control, operation is simple, and the method is easy for large-scale production; and 3, purity and yield of the product prepared by the method are high and both can reach 90% and above.
